Conference: Genetic Recombination and Genome Rearrangments FASEB Summer Research Conference

该奖项是对将于2022年8月14日至19日在科罗拉多州斯普林斯举行的基因重组和基因组重组会议的支持。这是一个历史悠久的会议，自1985年以来每两年举行一次。会议将包括8个全体会议，每个会议将有6至8个20分钟的发言。三分之二的演讲者是受邀的，其余的将来自贡献的摘要，重点是早期职业科学家。这次会议将有200多人参加，代表从实习生到成熟的PI的所有职业阶段。委员会将特别努力为不同的初级科学家提供全体演讲和简短的海报演讲机会。值得注意的是，国家科学基金会的所有资金将用于支持受训人员和年轻研究人员的参与，重点是那些代表人数不足的群体以及有经济需要的人。会议将集中讨论重组及其对染色体分离、DNA修复、基因组重排和突变的影响。这些主题将从多个角度进行探索，包括对重组所涉及的蛋白质的结构和生物物理分析，以及对重组对基因组结构的影响的基因组分析。会议将强调在DNA损伤反应、染色质重塑以及复制和重组的一般过程中应用结构生物学、分子遗传学和生物化学的尖端方法所推动的突破。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is for support of the conference Genetic Recombination and Genome Rearrangements, to be held August 14-19, 2022 in Steamboat Springs, Colorado. This is a well-established conference that has occurred biennially since 1985. The meeting will include 8 plenary sessions, each of which will have 6 to 8 20 minute presentations. Two thirds of the speakers are by invitation, and the remainder will be from contributed abstracts, with an emphasis on early career scientists. This meeting will have over 200 participants representing all career stages, from trainees to established PI’s. The committee will make a special effort to provide plenary speaking opportunities and short poster talks to diverse junior scientists as well. Notably, all NSF funds will be used to support participation by trainees and young investigators, with an emphasis on those from under-represented groups as well as those with financial need. The conference will focus on the topic of recombination and its implications for chromosome segregation, DNA repair, genome rearrangement, and mutation. These topics will be explored from multiple perspectives,including structural and biophysical analyses of the proteins involved in recombination, and genomic analyses of the consequences of recombination for genome structure. The meeting will emphasize breakthroughs spurred by cutting-edge approaches from structural biology, molecular genetics, and biochemistry as applied to DNA damage responses, chromatin remodeling, and the general processes of replication and recombination.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.