Collaborative Research: NSF-DFG: Confine: Sculpting Confined Fluids for Transport using Self-Organization and Information Transfer

合作研究：NSF-DFG：限制：利用自组织和信息传输塑造受限流体以进行运输

• 批准号: 2234135
• 负责人: Anna Balazs
• 金额: $ 22.5万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2025-10-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2234135&HistoricalAwards=false
• 关键词: Collaborative; Research; NSF; DFG; Confine

The aim of this award is to create microfluidic platforms (micrometer-scale liquid channels) that harness energy released from chemical reactions and perform sustained mechanical work, ultimately enabling the development of portable fluidic devices with autonomous, biomimetic functionality. The (self-)regulation of fluid flow and transport across length scales in response to specific chemical signals is critical for realizing next generation smart micro- & nano-scale devices; it enables innovative alternatives to current microfluidic technology and establishes efficient and autonomous modes of chemical synthesis, sensing, and delivery. The findings from this award will have a transformative impact by uncovering the complex interplay among molecular-scale catalytic chemistry, chemical networks, and macroscopic transport in confined microfluidic geometries. Through collaborative training of the students, the work will contribute to the development of the next generation work force in scientific and engineering fields, which are ever increasingly requiring expertise across a range of disciplines.This award will examine the fundamental effects of molecular-scale chemistry on microscale flow of confined fluids, and, conversely, the effect of microscopic flow on chemical kinetics in microchambers. The collaborative team encompasses the unique and necessary skills to pursue this ambitious research, which will be performed through three complementary work packages, with findings from each work package revealing fundamental phenomena across different length and time scales. The first work package concentrates on multi-material 3D microprinting of microfluidic systems, the second targets active pumping mechanisms enabled by enzymes on surfaces and deformable posts. The third work package implements a superimposed self-organizing signal patterning process at the post arrays, arising from DNA strand displacement reaction networks. The latter reaction networks will then be coupled to active pumping by enzymes and sculpting of fluid flows. Through these studies, new modes of chemically induced motion and self-organization within confined fluids will be uncovered. Additionally, self-regulating materials that transmit chemical information to drive and control autonomous transport of micro- to macro-scale fluidic systems will be created. This award will advance knowledge and understanding across a range of different fields, from fundamental fluid mechanics and catalysis to chemical engineering and process design. Since flow and feedback are non-equilibrium processes, these studies will also provide new platforms for probing relationships among structure, dynamics, and non-equilibrium behavior.This project was awarded through the “Chemistry and Transport in Confined Spaces (NSF-DFG Confine)" opportunity, a collaborative solicitation that involves the National Science Foundation and Deutsche Forschungsgemeinschaft (DFG).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项的目的是创建微流体平台（微米级液体通道），该平台利用化学反应释放的能量并进行持续的机械工作，最终使具有自主性，仿生功能的便携式流体设备开发。响应特定化学信号的（自我）调节流体流量和跨长度范围的运输对于实现下一代智能微型和纳米级设备至关重要。实现当前微流体技术的创新替代方案，并建立化学合成，灵敏度和传递的有效和自主模式。该奖项的发现将通过在密闭微流体几何形状中揭示分子规模的催化化学，化学网络和宏观运输之间的复杂相互作用，从而产生变革性的影响。通过对学生的合作培训，这项工作将有助于在科学和工程领域的下一代劳动力的发展，这些劳动力越来越需要在一系列学科中进行专业知识。该奖项将研究分子规模化学对封闭斗式长笛流动流动的基本影响，相反，微观基础化学基础化学基础化学的影响。协作团队涵盖了进行这项雄心勃勃的研究的独特和必要的技能，该研究将通过三个完整的工作包进行，每个工作包的发现揭示了不同长度和时间尺度的基本现象。第一个工作包集中在微流体系统的多物质3D微图上，第二个目标是由酶在表面和可变形柱上启用的主动抽水机制。第三个工作包在后阵列上实现了叠加的自组织信号模式，这是由DNA链位移反应网络引起的。然后，以后的反应网络将通过酶和流体流塑料耦合到主动泵送。通过这些研究，将发现封闭流体中化学诱导的运动和自组织的新模式。此外，将创建自我调节的材料，以驱动和控制微尺度流体系统的自动运输和控制自动运输。该奖项将促进各种不同领域的知识和理解，从基本的流体机制和催化剂到化学工程和过程设计。 Since flow and feedback are non-equilibrium processes, these studies will also provide new platforms for probing relationships among structure, dynamics, and non-equilibrium behavior.This project was awarded through the “Chemistry and Transport in Confined Spaces (NSF-DFG Confine)” opportunity, a collaborative solicitation that involves the National Science Foundation and Deutsche Forschungsgemeinschaft (DFG).This award reflects NSF's法定使命，并通过评估诚实地认为，使用基金会的智力优点和更广泛的影响审查标准。