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CCI Phase I: NSF Center for Chemo-Mechanical Assembly

CCI 第一阶段：NSF 化学机械组装中心

基本信息

批准号：
1740630
负责人：
Anna Balazs
金额：
$ 180万
依托单位：
University of Pittsburgh
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1740630&HistoricalAwards=false
关键词：
CCI Phase NSF Center Chemo

项目摘要

Much as a river current carries a pebble, fluid flows can carry particulates such as nanoparticles and microcapsules. While mechanical pumps are conventionally used to drive fluid flow, chemical "pumps" can also propel fluid by using chemical reaction networks to create gradients in chemical concentrations and fluid densities. Researchers in the NSF Center for Chemo-Mechanical Assembly (CCMA) are creating new transformative tools to enable unprecedented control over fluid flow and particle organization in confined environments. These precisely controlled fluid flows enable the design of self-powered, self-sustaining systems that organize particles and are capable of performing complex functions such as an autonomous nanoparticle system that detects a chemical source and collectively delivers a response chemical to it resulting in a vital analysis or creation of a novel structure. The CCMA team includes expertise in catalysis, synthetic chemistry, physical chemistry, fluid flow, and modeling. In addition to providing the chemistry community with new chemical reaction network tools, CCMA is also contributing to science and technology workforce development by training students in multidisciplinary experimental and modeling techniques. Through its industry affiliates program, CCMA is engaging industry in student training and technology transfer. Concurrent with the research, the team is launching a vigorous program of education and outreach to the public. This includes expanding undergraduate and graduate research opportunities for underrepresented groups in research-based careers. The team is also participating in several large-scale public outreach programs including public lectures, designing hands-on traveling exhibits, and teaming with museums and science centers. Through collaborative research that combines innovative modeling and experimental studies, the NSF CCI Phase I: Center for Chemo-Mechanical Assembly (CCMA) is harnessing catalytic chemical reactions to introduce spatiotemporal chemical gradients that drive the flow of a surrounding fluid. This flow, in turn, enables the manipulation of the collective behavior of suspended particles to drive new modes of dynamic self-organization. The Center is developing novel approaches to cause directed transport of nano- and micron-scale materials, control particle organization in confined chambers, and establish new chemical routes for regulating non-equilibrium structure formation from particles in solution. These studies are providing the chemistry community with fundamentally new tools and knowledge, including new chemistries for the creation of catalytic cascades; determination of design rules for chemical feedback loops; demonstration of new modes of out-of-equilibrium assembly; and progress toward new understanding of the nonlinear behavior and auto-amplification emerging from these systems. Potential applications include the creation of standalone microfluidic devices that autonomously perform multi-stage chemical reactions and assays for portable biomedical applications; automated materials assembly in harsh environments; and small-scale factories that can operate autonomously to build microscale components for use in fine instrumentation and robotic systems, and, in parallel, to screen for optimal reaction parameters yielding micro-machines with specified properties. To generate excitement and public appreciation about this emerging area of chemistry, the CCMA team is participating in several large-scale public outreach programs at the participating institutions, including public lectures, hands-on traveling exhibits, and museum and science center projects.

就像河流携带鹅卵石一样，流体流动可以携带纳米颗粒和微胶囊等颗粒。虽然机械泵通常用于驱动流体流动，但化学“泵”也可以通过使用化学反应网络来推动流体，以产生化学浓度和流体密度的梯度。NSF化学机械组装中心（CCMA）的研究人员正在创造新的变革性工具，以实现对受限环境中流体流动和颗粒组织的前所未有的控制。这些精确控制的流体流动使得能够设计自供电、自维持的系统，该系统组织颗粒并且能够执行复杂的功能，例如自主纳米颗粒系统，该系统检测化学源并且集体地向其递送响应化学物质，从而导致重要的分析或新颖结构的创建。CCMA团队包括催化、合成化学、物理化学、流体流动和建模方面的专业知识。除了为化学界提供新的化学反应网络工具外，CCMA还通过培训学生掌握多学科实验和建模技术，为科学和技术人才的发展做出贡献。通过其行业分支机构计划，CCMA正在参与学生培训和技术转让的行业。在进行研究的同时，该团队正在启动一项强有力的教育和公众宣传计划。这包括扩大本科生和研究生的研究机会，为代表性不足的群体在研究为基础的职业生涯。该团队还参与了几个大型的公共宣传项目，包括公开讲座，设计动手旅行展览，并与博物馆和科学中心合作。通过结合创新建模和实验研究的合作研究，NSF CCI第一阶段：化学机械组装中心（CCMA）正在利用催化化学反应来引入时空化学梯度，从而驱动周围流体的流动。反过来，这种流动使悬浮颗粒的集体行为的操纵能够驱动新的动态自组织模式。该中心正在开发新的方法，以引起纳米和微米级材料的定向运输，控制密闭室中的颗粒组织，并建立新的化学路线来调节溶液中颗粒的非平衡结构形成。这些研究为化学界提供了全新的工具和知识，包括用于创建催化级联的新化学;确定化学反馈回路的设计规则;演示新的平衡组装模式;以及对这些系统中出现的非线性行为和自动放大的新理解。潜在的应用包括创建独立的微流体装置，其自主地执行用于便携式生物医学应用的多阶段化学反应和测定;在恶劣环境中的自动化材料组装;和小规模的工厂，可以自主运作，以建立微型组件，用于精密仪器和机器人系统，并在平行，筛选最佳反应参数，生产具有特定性能的微型机器。为了激发公众对这一新兴化学领域的热情和赞赏，CCMA团队正在参与参与机构的几个大型公共宣传计划，包括公开讲座，动手旅行展览以及博物馆和科学中心项目。

项目成果

期刊论文数量（25）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Chemically controlled shape-morphing of elastic sheets

DOI：
10.1039/d0mh00730g
发表时间：
2020-09-01
期刊：
MATERIALS HORIZONS
影响因子：
13.3
作者：
Manna, Raj Kumar;Shklyaev, Oleg E.;Balazs, Anna C.
通讯作者：
Balazs, Anna C.

Achieving Independent Control over Surface and Bulk Fluid Flows in Microchambers

实现微室中表面和本体流体流动的独立控制

DOI：
10.1021/acsami.0c21291
发表时间：
2021
期刊：
ACS Applied Materials & Interfaces
影响因子：
9.5
作者：
Tansi, Benjamin M.;Manna, Raj Kumar;Shklyaev, Oleg E.;Peris, Matthew L.;Balazs, Anna C.;Sen, Ayusman
通讯作者：
Sen, Ayusman

Silver-Based Self-Powered pH-Sensitive Pump and Sensor