EAGER: Microendoscopy-Guided Biopsy in Very Small Ducts

摘要#1351110Eric J.Seibel在这个迫切的项目中，提出了一种新的内窥镜医疗设备的工程设计。这一新方法将允许在直径1.7毫米的超薄且灵活的内窥镜中包括工作通道。新方法不是缩小传统内窥镜的照明、成像、冲洗和活检的单独通道，而是在提供冲洗和活检的工作通道的尖端放置一个超小型成像器。这一新的方法对临床影像具有革命性的意义，对加速光学活检的发展具有重要的帮助。工作通道将提供液体交换和组织真空、活组织检查和取回的关键要求。测试将涉及活检设备，即将上皮粘膜吸入切割室，该切割室连接到近端以进行活检取回。活组织检查装置将利用合成体模和体外猪肺的测试结果以迭代的方式进行修改。集成的显微内窥镜和活检设备将被制造和测试，以便内窥镜引导到特定的部位进行活检。荧光标记的细胞和微球将被注入管腔壁，因此活检的准确性和充分性将成为量化的里程碑。

Abstract#1351110Eric J. SeibelIn this EAGER project a new engineering design for an endoscopic medical device is proposed. This new approach will allow a working channel to be included within an ultrathin and flexible endoscope of 1.7-mm diameter. Instead of shrinking the conventional endoscope of separate channels for illumination, imaging, flushing, and biopsy; the new approach will place an ultrasmall imager at the tip of a working channel that provides flushing and biopsy. This new approach is transformative for clinical imaging and critically helpful for accelerating the development of optical biopsy. The working channel will provide the key requirements of fluid exchange and tissue vacuum, biopsy, and retrieval. Testing will involve the biopsy apparatus, which is suction of the epithelial mucosa into a cutting chamber that is connected to the proximal end for biopsy retrieval. The biopsy apparatus will be modified in an iterative manner using test results from a synthetic phantom and ex vivo pig lung. The integrated microendoscope and biopsy apparatus will be fabricated and tested for endoscopic guidance to specific sites for biopsy. Fluorescently labeled cells and microspheres will be injected into the luminal wall so that accuracy as well as adequacy of the biopsy will be the quantitative milestones.