IDR-Collaborative: Quantitative 3D Optical Tomographic Microscopy for Lung Cancer Diagnosis

IDR-Collaborative：用于肺癌诊断的定量 3D 光学断层显微术

• 批准号: 1014976
• 负责人: Eric Seibel
• 金额: $ 31.65万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1014976&HistoricalAwards=false
• 关键词: IDR; Collaborative; Quantitative; 3D; Optical

1014976SeibelA microscopic tool being developed by this team will allow quantitative absorption and fluorescence 3D imaging of cells and their organelles which can be correlated to the clinical standards of disease diagnosis for the first time. This project develops new fields of 3D quantitative microscopy in two important contrast modes that bridge a gap between clinical diagnosis and medical research. In addition, the technology of 3D image processing from quantitative CT imaging for disease diagnosis is being applied to microscopy in a unique collaboration.Textbooks of cell biology depict a cell as flat with two-dimensional features. If disease diagnosis is 3D and more quantitative and sensitive to disease onset, then these textbooks will likely change to more accurately represent the cell anatomy. Teaching students on cellular structures and functions may be significantly changed due to advancements of true 3D microscopy. Providing cytologists and molecular biologists with quantification tools will result in earlier diagnosis of lethal diseases like lung cancer and improved understanding of the disease mechanisms.

1014976Seibel 该团队正在开发的显微工具将能够对细胞及其细胞器进行定量吸收和荧光3D成像，这可以首次与疾病诊断的临床标准相关联。该项目以两种重要的对比模式开发了 3D 定量显微镜的新领域，弥合了临床诊断和医学研究之间的差距。此外，用于疾病诊断的定量 CT 成像的 3D 图像处理技术正在以独特的合作方式应用于显微镜。细胞生物学教科书将细胞描述为具有二维特征的扁平细胞。如果疾病诊断是 3D 的，并且更加定量并且对疾病发作更敏感，那么这些教科书可能会发生变化，以更准确地表示细胞解剖结构。由于真正的 3D 显微镜技术的进步，学生细胞结构和功能的教学可能会发生重大变化。 为细胞学家和分子生物学家提供量化工具将有助于早期诊断肺癌等致命疾病，并加深对疾病机制的了解。