LEAP-HI: Towards a Paradigm of Thrombosis-Free Blood-contacting Devices

LEAP-HI：迈向无血栓血液接触装置的典范

• 批准号: 2245427
• 负责人: Arun Kumar Kota
• 金额: $ 50万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2245427&HistoricalAwards=false
• 关键词: LEAP; HI; Towards; Paradigm; Thrombosis

Every year, treatment of cardiovascular diseases requires thousands of heart assists, hundreds of thousands of heart valves, millions of coronary stents, tens of millions of hemodialyzers, and hundreds of millions of catheters. In all these medical devices, the main cause of morbidity and mortality is blood-clotting, which results in billions of dollars in medical costs and lost productivity. This Leading Engineering for America's Prosperity, Health, and Infrastructure (LEAP-HI) award supports fundamental research to help reduce blood-clotting in medical devices. The research will use promising flexible materials and clotting-resistant coatings to address blood-clotting at the molecular-scale, micro-scale and the device-scale. To accomplish this, the research will be conducted by a multidisciplinary team including experts in chemistry, chemical engineering, mechanical engineering, materials science and biomedical engineering. The results of the research have the potential to save millions of lives and billions of dollars each year, thereby directly contributing to America’s health and prosperity. Furthermore, these efforts will encourage STEM participation of underrepresented minorities and positively impact engineering education.Thrombosis in blood-contacting devices is primarily due to poor blood-material interactions in quasi-static conditions, and flow stagnation and supraphysiological shear stresses in dynamic conditions. This research hypothesizes that a combination of tailored hydration layers and flexible materials can lead to thrombosis-free blood-contacting devices. A multidisciplinary team will test this hypothesis through molecular dynamics simulations to understand the role of hydration layers, interfacial spectroscopy to experimentally characterize the hydration layers, fabrication of novel anti-thrombotic coatings based on the molecular dynamics simulations and interfacial spectroscopy, micro-scale evaluation of the blood-material interactions, and device-scale combination of the novel anti-thrombotic coatings and flexible materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

每年，心血管疾病的治疗需要数千个心脏辅助器、数十万个心脏瓣膜、数百万个冠状动脉支架、数千万个血液透析器和数亿个导管。在所有这些医疗设备中，发病率和死亡率的主要原因是凝血，这导致数十亿美元的医疗成本和生产力损失。这个领先的工程为美国的繁荣，健康和基础设施（LEAP-HI）奖支持基础研究，以帮助减少血液凝固的医疗设备。该研究将使用有前途的柔性材料和抗凝血涂层来解决分子尺度，微观尺度和设备尺度的血液凝固问题。为了实现这一目标，该研究将由一个多学科团队进行，包括化学，化学工程，机械工程，材料科学和生物医学工程专家。该研究的结果有可能每年挽救数百万人的生命和数十亿美元，从而直接为美国的健康和繁荣做出贡献。此外，这些努力将鼓励代表性不足的少数群体参与STEM，并对工程教育产生积极影响。血液接触装置中的血栓形成主要是由于准静态条件下血液与材料的相互作用较差，以及动态条件下的流动停滞和超生理剪切应力。这项研究假设，定制的水合层和柔性材料的组合可以导致无血栓的血液接触装置。一个多学科团队将通过分子动力学模拟来测试这一假设，以了解水合层的作用，界面光谱学实验表征水合层，基于分子动力学模拟和界面光谱学制造新型抗血栓涂层，血液-材料相互作用的微观评价，和设备规模的组合，该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查进行评估，被认为值得支持的搜索.