Galectin signature in pregnancy: defining the contribution of galectin-3

妊娠期半乳糖凝集素特征：定义半乳糖凝集素 3 的贡献

• 批准号: 254562950
• 负责人: Professorin Dr. Sandra Maria Blois
• 金额: --
• 依托单位: Klinik für Geburtshilfe und Pränatalmedizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/254562950?language=en
• 关键词: Galectin; signature; pregnancy; defining; contribution

Galectin-3, a chimera type carbohydrate-binding protein, plays a major role in biological processes such as growth, cell adhesion, proliferation, differentiation, cell-cycle progression, apoptosis, angiogenesis and immune system regulation. This lectin is abundant in the female tract and its expression is increased during pregnancy. However, the physiological role of galectin-3 over gestation remains to be elucidated. In the current proposal, we intend to define and characterize the contribution of gal-3 to the process of gestation. First of all we would like to define its role during the angiogenesis process associated with pregnancy. Next, we will focus on the contributions of fetal- and maternally- derived gal-3 to the pregnancy process and finally we will investigate the balance of gal-3 expression associated with pregnancy disorders (with special focus on spontaneous abortion, preeclampsia and gestational diabetes). We aim to define the galectin signature in pathological pregnancies encoring a precise early diagnosis for pregnancy complications. Thus, our results will contribute to the understanding of the physiological role played by galectin-3 adding valuable information to the management of diseases over gestation.

半乳糖凝集素-3（Galectin-3）是一种嵌合型碳水化合物结合蛋白，在生长、细胞粘附、增殖、分化、细胞周期进程、凋亡、血管生成和免疫系统调节等生物学过程中发挥重要作用。这种凝集素在女性生殖道中含量丰富，其表达在妊娠期间增加。然而，半乳糖凝集素-3在妊娠期间的生理作用仍有待阐明。在目前的建议中，我们打算定义和描述半乳糖醛酸-3对妊娠过程的贡献。首先，我们想确定它在与妊娠相关的血管生成过程中的作用。接下来，我们将关注胎儿和母体来源的gal-3对妊娠过程的贡献，最后我们将研究与妊娠障碍相关的gal-3表达的平衡（特别关注自然流产、先兆子痫和妊娠糖尿病）。我们的目的是确定半乳糖凝集素的签名在病理妊娠encoring一个准确的早期诊断妊娠并发症。因此，我们的研究结果将有助于了解半乳糖凝集素-3所发挥的生理作用，为妊娠期疾病的管理提供有价值的信息。

项目成果

Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency

• DOI: 10.1038/s41419-020-02791-5
• 发表时间: 2020-07-23
• 期刊: CELL DEATH & DISEASE
• 影响因子: 9
• 作者: Freitag, Nancy;Tirado-Gonzalez, Irene;Blois, Sandra M.
• 通讯作者: Blois, Sandra M.