Short- and Long-Range Structural Complexity from Ortho-arylene Foldamers

邻亚芳基折叠体的短程和长程结构复杂性

基本信息

  • 批准号:
    2304670
  • 负责人:
  • 金额:
    $ 48万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-06-01 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry, Professor C. Scott Hartley of Miami University will investigate methods by which the folding of non-biological molecules can be controlled. Biochemical systems make use of molecules that are both large and structurally complex. This combination is necessary for the remarkable sophistication, and thus function, of biochemical systems. Constructing comparable non-biological molecules is currently beyond the capabilities of synthetic chemistry. Nature’s strategy for generating structural complexity is by folding a long chain molecule into a specific shape. This research project aims to increase our understanding of the factors that govern the folding of long chain molecules. The ability to control molecular folding into complex 3D structures is important for advanced applications in molecular recognition and catalysis. The work will involve graduate students and undergraduates, who will be trained in synthetic and physical organic chemistry. Additional broader impacts include the development of a new teaching laboratory activity on attractive interactions relevant to molecular folding and work with a program from a consortium of Ohio universities supporting students from underrepresented backgrounds.This project aims to study the folding of a class of non-biological molecules called “foldamers” and to develop two strategies for controlling their folding into 3D structures. More specifically, this project will focus on studying ortho-arylene foldamers. ortho-Phenylenes are a simple class of aromatic foldamers that exhibit two very useful properties: their folded structures can be determined in solution with great precision using nuclear magnetic resonance (NMR) spectroscopy and computational chemistry, and their folding propensities are weak enough to be easily perturbed. These properties make them well suited to progressing from secondary to tertiary structure, a current challenge for foldamers research. In the first strategy, the folding of chains that mix attractive and repulsive interactions within a single molecule will be studied. By programming folding through the incorporation of pyrazine-2,3-diyl units into the sequence, complex structures will be obtained that are to be used to construct the coil segments necessary for tertiary structure. In the second strategy, cage structures incorporating multiple o-phenylene units will be investigated as simple examples of tertiary structure. Emphasis will be placed on understanding how the folding of the o-phenylenes responds to cage geometry and the inclusion of guest molecules. This research has the potential to provide access to and understanding of fundamentally new molecular folder systems to build complex non-biological structures with great potential for binding small molecule analytes and the potential for providing a new molecular scaffold for catalysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系大分子、超分子和纳米化学项目的支持下,C。迈阿密大学的斯科特·哈特利将研究控制非生物分子折叠的方法。生物化学系统利用的分子既大又结构复杂。这种结合对于生物化学系统的显著复杂性和功能是必要的。构建可比较的非生物分子目前超出了合成化学的能力。大自然产生结构复杂性的策略是将长链分子折叠成特定形状。这个研究项目旨在增加我们对长链分子折叠的因素的理解。控制分子折叠成复杂3D结构的能力对于分子识别和催化的高级应用是重要的。 这项工作将涉及研究生和本科生,他们将接受合成和物理有机化学方面的培训。其他更广泛的影响包括开发一个新的教学实验室活动,与分子折叠相关的吸引力相互作用,并与俄亥俄州大学联盟的一个项目合作,支持来自代表性不足背景的学生。该项目旨在研究一类称为“foldamer”的非生物分子的折叠,并开发两种控制其折叠成3D结构的策略。 更具体地说,本项目将集中研究邻亚芳基折叠体。邻亚苯基是一类简单的芳香族折叠体,具有两个非常有用的性质:它们的折叠结构可以在溶液中使用核磁共振(NMR)光谱和计算化学非常精确地确定,并且它们的折叠倾向足够弱,很容易被扰动。这些特性使它们非常适合从二级结构发展到三级结构,这是折叠体研究目前面临的挑战。在第一种策略中,将研究在单个分子内混合吸引和排斥相互作用的链的折叠。 通过将吡嗪-2,3-二基单元并入序列中来编程折叠,将获得用于构建三级结构所需的卷曲片段的复杂结构。在第二种策略中,笼状结构纳入多个邻亚苯基单元将作为简单的三级结构的例子进行研究。重点将放在理解如何折叠的邻苯响应笼的几何形状和包括客体分子。 这项研究有可能提供访问和理解从根本上新的分子折叠系统,以建立复杂的非生物结构,具有结合小分子分析物的巨大潜力,并有可能提供一个新的分子支架催化。该奖项反映了NSF的法定使命,并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Observing the Transient Assembly and Disassembly of Carboxylic Anhydrides in the Organic Chemistry Laboratory
  • DOI:
    10.1021/acs.jchemed.3c00731
  • 发表时间:
    2023-12
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Sumalatha Peddi;Jacob R. Franklin;C. S. Hartley
  • 通讯作者:
    Sumalatha Peddi;Jacob R. Franklin;C. S. Hartley
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Christopher Hartley其他文献

ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE BIOPSY OF THE PANCREAS AND DIRECT ORAL ANTICOAGULANTS: RANDOMIZED CONTROLLED PRECLINICAL TRIAL
  • DOI:
    10.1016/j.gie.2022.04.1255
  • 发表时间:
    2022-06-01
  • 期刊:
  • 影响因子:
    7.500
  • 作者:
    Ana Garcia Garcia de Paredes;Ariosto H. Hernandez-Lara;Christopher Hartley;Rajiv K. Pruthi;Rondell Graham;Jad P. AbiMansour;Eric J. Vargas;Andrew C. Storm;Ferga C. Gleeson;Michael J. Levy;Elizabeth Rajan
  • 通讯作者:
    Elizabeth Rajan
1452 Steatosis Evaluation in the Digital Age: What Can Machines Tell Us About Our Methods?
数字时代的脂肪变性评估:机器能告诉我们关于我们方法的什么?
  • DOI:
    10.1016/j.labinv.2024.103691
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
    4.200
  • 作者:
    Saadiya Nazli;Abdelrahman Shabaan;Bashar Hasan;Byoung Uk Park;Rofyda Elhalaby;Priyadharshini Sivasubramaniam;Adilson DaCosta;Lindsey Smith;Rondell Graham;Christopher Hartley;Daniela Allende;Murli Krishna;Marcela Salomao;Rish Pai;Kristina Matkowskyj;Hee Eun Lee;Stephen Lagana;Zongming (Eric) Chen;Jason Lewis;Andrew Cannon;Roger Moreira
  • 通讯作者:
    Roger Moreira
Sa2054 QUANTITATIVE ASSESSMENT OF DUPILUMAB TREATMENT IN PEDIATRIC PATIENTS CHARACTERIZED BY AN ARTICFICAL INTELLIGENCE ANALYSIS OF HISTOPATHOLOGIC FEATURES OF EOSINOPHILIC ESOPHAGITIS
  • DOI:
    10.1016/s0016-5085(24)01888-2
  • 发表时间:
    2024-05-18
  • 期刊:
  • 影响因子:
  • 作者:
    Puanani Hopson;Andrew Cannon;Roland Tian;Luisa Ricaurte Archila;Priyadharshini Sivasubramaniam;Ameya Patil;Christopher Hartley;Imad Absah;Roger K. Moreira
  • 通讯作者:
    Roger K. Moreira
Accuracy of Preliminary Pathology for Robotic Bronchoscopic Biopsy
  • DOI:
    10.1016/j.athoracsur.2022.11.022
  • 发表时间:
    2023-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Linh H. Vu;Alejandra Yu Lee-Mateus;Eric S. Edell;Christopher Hartley;Robert A. Vierkant;Sebastian Fernandez-Bussy;Janani Reisenauer
  • 通讯作者:
    Janani Reisenauer
ASSESSMENT OF A NOVEL ARTIFICIAL INTELLIGENCE-ENHANCED APPLICATION DESIGNED TO ASSIST THE CYTOLOGIC EVALUATION OF BILIARY STRICTURES: RESULTS OF A DOUBLE-BLINDED, PRAGMATIC TRIAL
评估一种旨在辅助胆道狭窄细胞学评估的新型人工智能增强应用程序:一项双盲、实用试验的结果
  • DOI:
    10.1016/j.gie.2023.04.1937
  • 发表时间:
    2023-06-01
  • 期刊:
  • 影响因子:
    7.500
  • 作者:
    Neil Marya;Christopher Hartley;Patrick Powers;Melanie Bois;Sarah Kerr;Judith Jebastin Thangaiah;Mary Kittle Francis;Marie Passow;Daniel Norton;Ferga Gleeson;Barham Abu Dayyeh;Aliana Bofill-Garcia;Vinay Chandrasekhara;Gregory Gores;Benjamin Kipp;Ryan Law;John Martin;Bret Petersen;Lewis Roberts;Andrew Storm;Michael Levy
  • 通讯作者:
    Michael Levy

Christopher Hartley的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Christopher Hartley', 18)}}的其他基金

MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer at Miami University
MRI:在迈阿密大学购买 400 MHz 核磁共振 (NMR) 波谱仪
  • 批准号:
    1919850
  • 财政年份:
    2019
  • 资助金额:
    $ 48万
  • 项目类别:
    Standard Grant
Dynamic control and self-assembly of ortho-phenylene foldamers
邻亚苯基折叠体的动态控制与自组装
  • 批准号:
    1904236
  • 财政年份:
    2019
  • 资助金额:
    $ 48万
  • 项目类别:
    Standard Grant
ortho-Phenylenes in Complex Foldamer Architectures
复杂Foldamer架构中的邻亚苯基
  • 批准号:
    1608213
  • 财政年份:
    2016
  • 资助金额:
    $ 48万
  • 项目类别:
    Standard Grant
o-Phenylenes: Controlled Folding and Directed Oxidative Planarization
邻亚苯基:受控折叠和定向氧化平坦化
  • 批准号:
    1306437
  • 财政年份:
    2013
  • 资助金额:
    $ 48万
  • 项目类别:
    Standard Grant
ortho-Phenylene Oligomers and Graphene Nanoribbons
邻亚苯基低聚物和石墨烯纳米带
  • 批准号:
    0910477
  • 财政年份:
    2009
  • 资助金额:
    $ 48万
  • 项目类别:
    Standard Grant

相似国自然基金

基于Relm-β核转位激活EndMT促进肺动脉高压研究肺心汤预防 Long COVID 机制
  • 批准号:
    2025JJ90008
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
维生素D调控巨噬细胞极化在改善“Long COVID”中作用和机制的分子流行病学研究
  • 批准号:
    82373643
  • 批准年份:
    2023
  • 资助金额:
    49 万元
  • 项目类别:
    面上项目
long non-coding RNA(lncRNA)-activatedby TGF-β(lncRNA-ATB)通过成纤维细胞影响糖尿病创面愈合的机制研究
  • 批准号:
    LQ23H150003
  • 批准年份:
    2023
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
Long-TSLP和Short-TSLP佐剂对新冠重组蛋白疫苗免疫应答的影响与作用机制
  • 批准号:
  • 批准年份:
    2021
  • 资助金额:
    58 万元
  • 项目类别:
    面上项目
水稻LONG PANICLE1基因调控穗长的分子机制研究
  • 批准号:
  • 批准年份:
    2021
  • 资助金额:
    30 万元
  • 项目类别:
    青年科学基金项目
long-TSLP诱导的M2型巨噬细胞调控肺成纤维细胞线粒体融合在哮喘气道重塑中的作用和机制
  • 批准号:
    81970032
  • 批准年份:
    2019
  • 资助金额:
    55.0 万元
  • 项目类别:
    面上项目
LONG8及其互作蛋白LGIP1调控水稻籽粒大小的分子机理研究
  • 批准号:
    31871219
  • 批准年份:
    2018
  • 资助金额:
    59.0 万元
  • 项目类别:
    面上项目
拟南芥微管结合蛋白Long Seed1调控种子大小的分子机制研究
  • 批准号:
    31770205
  • 批准年份:
    2017
  • 资助金额:
    60.0 万元
  • 项目类别:
    面上项目
long-TSLP和short-TSLP调控肺成纤维细胞有氧糖酵解在哮喘气道重塑中的作用和机制研究
  • 批准号:
    81700034
  • 批准年份:
    2017
  • 资助金额:
    20.0 万元
  • 项目类别:
    青年科学基金项目
哮喘气道上皮来源long-TSLP/short-TSLP失衡对气道重塑中成纤维细胞活化的分子机制研究
  • 批准号:
    81670026
  • 批准年份:
    2016
  • 资助金额:
    60.0 万元
  • 项目类别:
    面上项目

相似海外基金

Association analysis between short/long-range diffusion of non-tuberculosis mycobacterium bioaerosols and its infectious disease
非结核分枝杆菌生物气溶胶短/长程扩散与其传染病的关联分析
  • 批准号:
    20H04326
  • 财政年份:
    2020
  • 资助金额:
    $ 48万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Collaborative Research: RoL: FELS: EAGER: Determining the Interplay of Long- and Short-Range Interactions in Emergent Biological Collective Behavior
合作研究:RoL:FELS:EAGER:确定新兴生物集体行为中长程和短程相互作用的相互作用
  • 批准号:
    1838341
  • 财政年份:
    2018
  • 资助金额:
    $ 48万
  • 项目类别:
    Standard Grant
Collaborative Research: RoL: FELS: EAGER: Determining the Interplay of Long- and Short-Range Interactions in Emergent Biological Collective Behavior
合作研究:RoL:FELS:EAGER:确定新兴生物集体行为中长程和短程相互作用的相互作用
  • 批准号:
    1838331
  • 财政年份:
    2018
  • 资助金额:
    $ 48万
  • 项目类别:
    Standard Grant
Mechanisms regulating lncRNA short and long range signaling
lncRNA短程和长程信号传导的调节机制
  • 批准号:
    10584944
  • 财政年份:
    2017
  • 资助金额:
    $ 48万
  • 项目类别:
Mechanisms regulating lncRNA short and long range signaling
lncRNA短程和长程信号传导的调节机制
  • 批准号:
    9333036
  • 财政年份:
    2017
  • 资助金额:
    $ 48万
  • 项目类别:
Mechanisms regulating lncRNA short and long range signaling
lncRNA短程和长程信号传导的调节机制
  • 批准号:
    9901574
  • 财政年份:
    2017
  • 资助金额:
    $ 48万
  • 项目类别:
Mechanisms regulating lncRNA short and long range signaling
lncRNA短程和长程信号传导的调节机制
  • 批准号:
    10403749
  • 财政年份:
    2017
  • 资助金额:
    $ 48万
  • 项目类别:
A new method for long-range haplotype phasing with short-read sequencing data.
一种利用短读长测序数据进行长程单倍型定相的新方法。
  • 批准号:
    9048335
  • 财政年份:
    2016
  • 资助金额:
    $ 48万
  • 项目类别:
First-principles description of short- and long-range correlation effects in strongly correlated systems based on the wave function theory
基于波函数理论的强相关系统短程相关效应和长程相关效应的第一性原理描述
  • 批准号:
    15K17724
  • 财政年份:
    2015
  • 资助金额:
    $ 48万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
A Hybrid Satellite and Short-Range Transceiver System for Combining Fine-Scale GPS Locations with Long-Distance Tracking to Monitor Wildlife Movements, Behavior and Mortality
混合卫星和短程收发器系统,将精细 GPS 位置与长距离跟踪相结合,监测野生动物的活动、行为和死亡率
  • 批准号:
    1063364
  • 财政年份:
    2011
  • 资助金额:
    $ 48万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了