Deciphering Coarsening Dynamics and Cluster Migration using Experiments and Models
使用实验和模型解读粗化动力学和簇迁移
基本信息
- 批准号:2310496
- 负责人:
- 金额:$ 60万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
During the process known as coarsening, smaller objects merge together into larger and larger ones. This process occurs on many different length scales and plays an important role in living systems: nuclear proteins coarsen into condensed droplets, bacteria coalesce into multicellular aggregates, and animals aggregate into large groups. The dynamics of these biological systems are typically driven by long-range communication between the elements. It is currently not clear, however, how this communication and the motion of the elements are coupled and result in coarsening. This award will focus on the coarsening dynamics of clusters of Dictyostelium discoideum cells, an amoeboid system. These cells form small and isolated clusters that subsequently move together and coarsen into larger and larger ones. The communication in this system is provided by a secreted chemoattractant, a chemical that directs the motion of the cells and clusters. This award will quantify the dynamics of coarsening by measuring the number and size of clusters and the secretion of the chemoattractant as a function of time. In addition, the study will use traction force microscopy, a technique that uses beads on deformable substrates, to quantify the forces exerted by the clusters when they migrate and coalesce. Together, these measurements will provide a better understanding of the mechanisms that are responsible for the collective migration exhibited by clusters during coarsening. The experimental results will also be used to develop comprehensive mathematical models, which will generate predictions that can be experimentally verified, resulting in a two-way dialogue between experiments and modeling. In addition, this award will include the training of high school, undergraduate, and graduate students who will be directly involved in the proposed research. Finally, as part of this project, yearly “Dicty Days" will be organized at two local high schools. During these two-day events students will be able to perform simple hands-on experiments to help stimulate their interest in biological physics. These students will be integrated into the lab and taught how to design, carry out, and interpret experiments and simulations, with the goal of attracting diverse students to a career in the biophysical sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在被称为粗化的过程中,较小的物体合并成越来越大的物体。这个过程发生在许多不同的长度尺度上,在生命系统中起着重要的作用:核蛋白粗化成凝聚的液滴,细菌凝聚成多细胞聚集体,动物聚集成大群体。这些生物系统的动力学通常是由元素之间的远程通信驱动的。然而,目前尚不清楚这种通信和元素的运动是如何耦合并导致粗化的。该奖项将重点关注盘状骨细胞簇(一种变形虫系统)的粗化动力学。这些细胞形成小而孤立的簇,随后一起移动并变粗成越来越大的簇。这个系统中的通讯是由一种分泌的化学引诱剂提供的,这种化学物质指导细胞和细胞簇的运动。该奖项将通过测量簇的数量和大小以及化学引诱剂的分泌作为时间的函数来量化粗化的动态。此外,该研究将使用牵引力显微镜,这是一种在可变形基底上使用珠子的技术,以量化簇在迁移和聚合时施加的力。总之,这些测量将提供一个更好的理解机制,负责集体迁移的集群在粗化过程中表现出来。实验结果还将用于开发全面的数学模型,这些模型将产生可以通过实验验证的预测,从而实现实验和建模之间的双向对话。此外,该奖项将包括对直接参与拟议研究的高中生、本科生和研究生的培训。最后,作为这个项目的一部分,每年的“迪蒂日”将在当地的两所高中组织。在这两天的活动中,学生将能够进行简单的动手实验,以帮助激发他们对生物物理学的兴趣。这些学生将被整合到实验室,学习如何设计、执行和解释实验和模拟,目的是吸引不同的学生从事生物物理科学的职业。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Wouter-Jan Rappel其他文献
CONSISTENT SPATIOTEMPORAL VECTORS IN ATRIAL FIBRILLATION PREDICT RESPONSE TO ABLATION
- DOI:
10.1016/s0735-1097(21)01693-4 - 发表时间:
2021-05-11 - 期刊:
- 影响因子:
- 作者:
Prasanth Ganesan;Neal Bhatia;Thomas C. Beck;Namita Ravi;Albert Rogers;David Krummen;Paul Wang;Wouter-Jan Rappel;Sanjiv Narayan - 通讯作者:
Sanjiv Narayan
RELATIONSHIP OF LOCALIZED SOURCES FOR HUMAN ATRIAL FIBRILLATION TO COMPLEX FRACTIONATED ELECTROGRAMS
- DOI:
10.1016/s0735-1097(12)60592-0 - 发表时间:
2012-03-27 - 期刊:
- 影响因子:
- 作者:
Sanjiv M. Narayan;Michael W. Enyeart;David Krummen;Wouter-Jan Rappel;Ruchir Sehra - 通讯作者:
Ruchir Sehra
INTRACLASS CORRELATIONS OF VOLTAGE, FRACTIONATED ELECTROGRAMS, AND DOMINANT FREQUENCY IN PATIENTS WHERE LOCALIZED ABLATION TERMINATED PERSISTENT ATRIAL FIBRILLATION
- DOI:
10.1016/s0735-1097(19)31129-5 - 发表时间:
2019-03-12 - 期刊:
- 影响因子:
- 作者:
Albert J. Rogers;Nosheen Moosvi;Abhinav Singh;Mahmood Alhusseini;Tina Baykaner;Paul Clopton;Wouter-Jan Rappel;Paul Wang;Sanjiv Narayan - 通讯作者:
Sanjiv Narayan
Global versus local matrix remodeling drives rotational versus invasive collective migration of epithelial cells
整体与局部的基质重塑驱动上皮细胞的旋转式与侵袭性集体迁移
- DOI:
10.1016/j.devcel.2024.11.021 - 发表时间:
2025-03-24 - 期刊:
- 影响因子:8.700
- 作者:
Sural K. Ranamukhaarachchi;Alyssa Walker;Man-Ho Tang;William D. Leineweber;Sophia Lam;Wouter-Jan Rappel;Stephanie I. Fraley - 通讯作者:
Stephanie I. Fraley
PO-05-130 DEMONSTRATING THE IMPACT OF LESION ORIENTATION ON ABLATION EFFICIENCY IN AN ANISOTROPIC MODEL OF PERSISTENT ATRIAL FIBRILLATION
PO-05-130 在持续性心房颤动各向异性模型中展示病变取向对消融效率的影响
- DOI:
10.1016/j.hrthm.2024.03.1365 - 发表时间:
2024-05-01 - 期刊:
- 影响因子:5.700
- 作者:
Michael Reiss;Mahesh K. Mulimani;Stefan Luther;Joseph G. Akar;Wouter-Jan Rappel;Fadi G. Akar;James Hummel - 通讯作者:
James Hummel
Wouter-Jan Rappel的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Wouter-Jan Rappel', 18)}}的其他基金
Integrating Four-Dimensional Cell Migration Modeling with Quantitative Experiments
将四维细胞迁移模型与定量实验相结合
- 批准号:
1953469 - 财政年份:2020
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
A Combined Theoretical and Experimental Approach to Study Collective Cell Migration
研究集体细胞迁移的理论与实验相结合的方法
- 批准号:
1707637 - 财政年份:2018
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
相似海外基金
Collaborative Research: Quantifying the Coarsening Kinetics of Supported Metal Nanoparticles Using Time-resolved Electron Microscopy, Data Analytics and Simulations
合作研究:利用时间分辨电子显微镜、数据分析和模拟量化支撑金属纳米颗粒的粗化动力学
- 批准号:
2303085 - 财政年份:2023
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Collaborative Research: Quantifying the Coarsening Kinetics of Supported Metal Nanoparticles Using Time-resolved Electron Microscopy, Data Analytics and Simulations
合作研究:利用时间分辨电子显微镜、数据分析和模拟量化支撑金属纳米颗粒的粗化动力学
- 批准号:
2303084 - 财政年份:2023
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Physics-inspired Coarsening for Turbulent Flow Simulations
用于湍流模拟的物理启发粗化
- 批准号:
2152373 - 财政年份:2022
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
ISS: Collaborative Research: Bimodal Colloidal Assembly, Coarsening and Failure: Decoupling Sedimentation and Particle Size Effects
ISS:合作研究:双峰胶体组装、粗化和失效:解耦沉积和粒径效应
- 批准号:
2025613 - 财政年份:2020
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
ISS: Collaborative Research: Bimodal Colloidal Assembly, Coarsening and Failure: Decoupling Sedimentation and Particle Size Effects
ISS:合作研究:双峰胶体组装、粗化和失效:解耦沉积和粒径效应
- 批准号:
2025453 - 财政年份:2020
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Quantifying the Coarsening Kinetics of Supported Metal Nanoparticles Using Time-resolved Electron Microscopy, Data Analytics and Simulations
使用时间分辨电子显微镜、数据分析和模拟量化负载金属纳米颗粒的粗化动力学
- 批准号:
1809398 - 财政年份:2018
- 资助金额:
$ 60万 - 项目类别:
Continuing Grant
Coarsening and growth of meta-stable gamma''-precipitates in Nickel-base Superalloys
镍基高温合金中亚稳γ-析出物的粗化和生长
- 批准号:
387117768 - 财政年份:2017
- 资助金额:
$ 60万 - 项目类别:
Priority Programmes
Study on coarsening of fine particulate matter (PM) during coal combustion
煤炭燃烧过程细颗粒物(PM)粗化研究
- 批准号:
16K14178 - 财政年份:2016
- 资助金额:
$ 60万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Environment-dependent coarsening of supported metallic nanoclusters
负载金属纳米团簇的环境依赖性粗化
- 批准号:
1507223 - 财政年份:2015
- 资助金额:
$ 60万 - 项目类别:
Standard Grant
Coarsening of soil properties and topography for large scale fully coupled subsurface-land-atmosphere models
大规模完全耦合地下-陆地-大气模型的土壤特性和地形粗化
- 批准号:
246186161 - 财政年份:2013
- 资助金额:
$ 60万 - 项目类别:
Research Units