Conference: Genomic Consequences of Meiotic Drive Workshop

“减数分裂驱动的基因组后果”研讨会将于2023年6月在瑞士阿罗拉举行，将有20-30人参加。减数分裂驱动是一种发生在大多数真核生物群体（哺乳动物，植物，昆虫，真菌，线虫）中的现象。在减数分裂驱动系统中的配子发生导致两条同源染色体中的一条，而不是配子发生导致配子中的相等代表性。因此，减数分裂驱动基因座欺骗了正常的孟德尔分离，这有助于它们在种群中的传播。减数分裂驱动有几个潜在的进化后果，但它也留下了一个深刻的签名物种的基因组与驱动程序。大量的基因组数据，现在可用于减数分裂驱动系统将有助于综合审查的减数分裂驱动的基因组后果。我们的方法是将研究人员聚集在一起，介绍他们在减数分裂驱动的基因组后果方面的工作，然后集思广益，起草一篇综合该领域的评论文章。该模型遵循2016年和2020年发表的关于减数分裂驱动不同方面的两篇先前评论。我们的工作将为减数分裂驱动的专家和那些需要考虑减数分裂驱动作为自己研究问题的切线的人提供该领域的全面概述。这项工作将对整个遗传学/基因组学社区产生影响。该研讨会还旨在提升新来者对该领域的研究。我们的与会者名单是有目的地丰富的早期职业研究人员和来自不同背景的研究人员。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

The “Genomic Consequences of Meiotic Drive” Workshop will be held in Arolla, Switzerland in June 2023 and involve 20-30 attendees. Meiotic drive is a phenomenon that occurs across most eukaryotic groups of organisms (mammals, plants, insects, fungi, nematodes). Instead of gametogenesis resulting in equal representation in the gametes, gametogenesis in a meiotic drive system results in mostly one of the two homologous chromosomes. Thus, meiotic drive loci cheat normal Mendelian segregation which aids their spread through populations. Meiotic drive has several potential evolutionary consequences, but it also leaves a profound signature on the genomes of species with drivers. The enormous amount of genomic data now available for meiotic drive system will facilitate a synthetic review of the genomic consequences of meiotic drive. Our approach is to bring researchers together to present their work on genomic consequences of meiotic drive, then brainstorm and draft a review article that synthesizes the field. This model follows two prior reviews on different aspects of meiotic drive published in 2016 and 2020. Our work will provide a comprehensive overview of the field for both specialists in meiotic drive and those who need to consider meiotic drive as a tangent to their own research questions. This work will be impactful to the genetics/genomics community as a whole. The workshop is also designed to elevate the research of newcomers to this field. Our attendee list is purposefully enriched for early career researchers and researchers from diverse backgrounds. The format of the workshop allows for easy interaction between researchers from all levels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.