Conference: Genomic Consequences of Meiotic Drive Workshop

“减数分裂驱动的基因组后果”研讨会将于2023年6月在瑞士阿罗拉举行，有20-30名与会者。减数分裂驱动是一种发生在大多数真核生物群体（哺乳动物、植物、昆虫、真菌、线虫）中的现象。在减数分裂驱动系统中，配子发生的结果主要是两条同源染色体中的一条，而不是在配子中产生相等的代表。因此，减数分裂驱动基因座欺骗了正常的孟德尔分离，这有助于它们在种群中传播。减数分裂驱动有几个潜在的进化后果，但它也在具有驱动因子的物种的基因组上留下了深刻的印记。大量的基因组数据现在可用于减数分裂驱动系统将促进减数分裂驱动的基因组后果的综合审查。我们的方法是将研究人员聚集在一起，介绍他们在减数分裂驱动的基因组后果方面的工作，然后集思广益，起草一篇综合该领域的综述文章。该模型遵循了先前在2016年和2020年发表的两篇关于减数分裂驱动不同方面的综述。我们的工作将为减数分裂驱动专家和那些需要考虑减数分裂驱动作为切线到他们自己的研究问题的专家提供该领域的全面概述。这项工作将对整个遗传学/基因组学社区产生影响。该研讨会还旨在提升新来者对该领域的研究。我们的与会者名单有意丰富了早期职业研究人员和来自不同背景的研究人员。研讨会的形式允许来自各个层次的研究人员之间的轻松互动。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The “Genomic Consequences of Meiotic Drive” Workshop will be held in Arolla, Switzerland in June 2023 and involve 20-30 attendees. Meiotic drive is a phenomenon that occurs across most eukaryotic groups of organisms (mammals, plants, insects, fungi, nematodes). Instead of gametogenesis resulting in equal representation in the gametes, gametogenesis in a meiotic drive system results in mostly one of the two homologous chromosomes. Thus, meiotic drive loci cheat normal Mendelian segregation which aids their spread through populations. Meiotic drive has several potential evolutionary consequences, but it also leaves a profound signature on the genomes of species with drivers. The enormous amount of genomic data now available for meiotic drive system will facilitate a synthetic review of the genomic consequences of meiotic drive. Our approach is to bring researchers together to present their work on genomic consequences of meiotic drive, then brainstorm and draft a review article that synthesizes the field. This model follows two prior reviews on different aspects of meiotic drive published in 2016 and 2020. Our work will provide a comprehensive overview of the field for both specialists in meiotic drive and those who need to consider meiotic drive as a tangent to their own research questions. This work will be impactful to the genetics/genomics community as a whole. The workshop is also designed to elevate the research of newcomers to this field. Our attendee list is purposefully enriched for early career researchers and researchers from diverse backgrounds. The format of the workshop allows for easy interaction between researchers from all levels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.