Conference: Genomic Consequences of Meiotic Drive Workshop

会议：减数分裂驱动研讨会的基因组后果

• 批准号: 2312190
• 负责人: Robert Unckless
• 金额: $ 4.68万
• 依托单位: University of Kansas Center for Research Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2312190&HistoricalAwards=false
• 关键词: Conference; Genomic; Consequences; Meiotic; Drive

The “Genomic Consequences of Meiotic Drive” Workshop will be held in Arolla, Switzerland in June 2023 and involve 20-30 attendees. Meiotic drive is a phenomenon that occurs across most eukaryotic groups of organisms (mammals, plants, insects, fungi, nematodes). Instead of gametogenesis resulting in equal representation in the gametes, gametogenesis in a meiotic drive system results in mostly one of the two homologous chromosomes. Thus, meiotic drive loci cheat normal Mendelian segregation which aids their spread through populations. Meiotic drive has several potential evolutionary consequences, but it also leaves a profound signature on the genomes of species with drivers. The enormous amount of genomic data now available for meiotic drive system will facilitate a synthetic review of the genomic consequences of meiotic drive. Our approach is to bring researchers together to present their work on genomic consequences of meiotic drive, then brainstorm and draft a review article that synthesizes the field. This model follows two prior reviews on different aspects of meiotic drive published in 2016 and 2020. Our work will provide a comprehensive overview of the field for both specialists in meiotic drive and those who need to consider meiotic drive as a tangent to their own research questions. This work will be impactful to the genetics/genomics community as a whole. The workshop is also designed to elevate the research of newcomers to this field. Our attendee list is purposefully enriched for early career researchers and researchers from diverse backgrounds. The format of the workshop allows for easy interaction between researchers from all levels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

2023年6月将在瑞士阿罗拉举办“梅奥里亚驱动的基因组后果”研讨会，有20-30人参加。减数分裂驱动是一种发生在大多数真核生物(哺乳动物、植物、昆虫、真菌、线虫)中的现象。在减数分裂驱动系统中，配子发生不会导致配子中的平等表达，而是主要产生两条同源染色体中的一条。因此，减数分裂驱动基因座欺骗了正常的孟德尔分离，这有助于它们在种群中传播。减数分裂驱动有几个潜在的进化后果，但它也在具有驱动因素的物种的基因组上留下了深刻的签名。目前可用于减数分裂驱动系统的大量基因组数据将有助于对减数分裂驱动的基因组后果进行综合审查。我们的方法是将研究人员聚集在一起，展示他们关于减数分裂驱动的基因组后果的工作，然后集思广益，起草一篇综述文章，综合这一领域。这一模型是在2016年和2020年发表的关于减数分裂驱动的两个不同方面的先前综述之后建立的。我们的工作将为减数分裂驱动的专家和那些需要将减数分裂驱动视为自己研究问题的切线的人提供该领域的全面概述。这项工作将对整个遗传学/基因组学社区产生影响。研讨会的设计也是为了将新手的研究提升到这一领域。我们的与会者名单是专门为早期职业研究人员和来自不同背景的研究人员而设计的。研讨会的形式允许来自各个层面的研究人员之间的轻松互动。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。