An Injectable Glucose Biosensor Based on a Self-cleaning Membrane & NIR FRET Assay

基于自清洁膜的可注射葡萄糖生物传感器

基本信息

项目摘要

Diabetes affects millions of people in the United States. To avoid serious health risks, blood sugar must be measured and kept at normal levels. Continuous blood sugar monitors are used to replace finger prick tests. This allows measurement of sugar levels both day and night. Current continuous sugar monitors use a small sensor probe like a wire that is inserted through the skin. This is usually put in the arm and is replaced about every two weeks. A transmitter is put on the skin over the sensor to communicate to a smartphone. This research seeks to develop a sugar sensor that is easier to use. The sensor will be the size of a grain of rice. This small size allows it to be injected into the tissue of the wrist with a needle. Then the sugar levels can be comfortably monitored with a device like a watch. This new sensor is expected to last 30 days or more. It will be sensitive to the change in the sugar like current sensors. It will also be convenient to use. This research will also provide training experiences to high school students and university students. This project seeks to develop a grain-of-rice size, injectable glucose biosensor to enable continuous monitoring with a wearable device. This will be accomplished by addressing challenges related to biocompatibility and optical glucose sensing through innovative biomaterials and assay chemistries, respectively. The scientific objectives include: (1) Develop an injectable biosensor comprised of a self-cleaning membrane and a near-infrared (NIR) fluorescence glucose sensing assay and sealing the assay within the membrane’s central cavity with self-closing caps. (2) Develop a wearable optical detection system to interrogate the biosensor and measure glucose levels (comprised of an LED and photodiode pair, without the need for an affixed transmitter). (3) Assess the biosensor’s ability to monitor glucose levels in vivo (rat model), as well as the membrane’s reduction of the foreign body reaction (FBR). Beyond allowing non-surgical injection, such a biosensor design affords convenient, non-invasive detection exclusively with a watch-like device The NIR fluorescence optical sensing is expected to enable glucose detection for individuals of all skin tones and body mass indices (BMIs). The results of this work are poised to have broad impact in the development of other implantable biosensors and devices. The self-cleaning membrane will advance knowledge in the role of active mechanisms rather than passive mechanisms for biofouling control, and hence improved biocompatibility. The NIR fluorescence assay will advance the knowledge of optical sensing methods that achieve exceptional in vitro stability, reversibility, dynamic range, and sensitivity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在美国,糖尿病影响着数百万人。为了避免严重的健康风险,必须测量血糖并将其保持在正常水平。连续血糖监测仪被用来代替手指穿刺试验。这样就可以测量白天和晚上的血糖水平。目前的连续血糖监测仪使用一种像电线一样的小传感器探头插入皮肤。这通常放在手臂上,大约每两周更换一次。在传感器的皮肤上放置一个发射器,与智能手机进行通信。这项研究旨在开发一种更容易使用的糖传感器。传感器将有一粒米那么大。这种小尺寸允许用针将其注射到手腕组织中。然后就可以用手表之类的设备轻松地监测血糖水平了。这种新型传感器预计可以使用30天或更长时间。它会像电流传感器一样对糖的变化很敏感。使用起来也会很方便。本研究也将为高中生和大学生提供训练经验。该项目旨在开发一种米粒大小、可注射的葡萄糖生物传感器,以实现可穿戴设备的连续监测。这将分别通过创新的生物材料和分析化学来解决与生物相容性和光学葡萄糖传感相关的挑战。科学目标包括:(1)开发一种可注射的生物传感器,由自清洁膜和近红外(NIR)荧光葡萄糖传感实验组成,并用自闭帽将实验密封在膜的中心腔内。(2)开发一种可穿戴光学检测系统,用于询问生物传感器并测量葡萄糖水平(由LED和光电二极管对组成,无需附加发射器)。(3)评估生物传感器在体内(大鼠模型)监测葡萄糖水平的能力,以及膜对异物反应(FBR)的减少能力。除了允许非手术注射外,这种生物传感器设计还提供了方便的非侵入性检测,仅使用类似手表的设备。近红外荧光光学传感有望实现所有肤色和体重指数(bmi)个体的葡萄糖检测。这项工作的结果将对其他植入式生物传感器和设备的发展产生广泛的影响。自清洁膜将促进对生物污染控制的主动机制而不是被动机制的认识,从而提高生物相容性。近红外荧光分析将推进光学传感方法的知识,实现卓越的体外稳定性,可逆性,动态范围和灵敏度。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Melissa Grunlan其他文献

42. Self-fitting Vaginal Stents from Biodegradable, Shape Memory Polymers
  • DOI:
    10.1016/j.jpag.2023.01.130
  • 发表时间:
    2023-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Arian Veyssi;Andrew Robinson;Elizabeth Cosgriff-Hernadez;Courteney Roberts;Felipe Beltran;Sarah Beck;Melissa Grunlan;Jennifer M. McCracken;Julie Hakim
  • 通讯作者:
    Julie Hakim

Melissa Grunlan的其他文献

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{{ truncateString('Melissa Grunlan', 18)}}的其他基金

Micropatterned Thermoresponsive Nanocomposite Hydrogel Surfaces with Self-Cleaning Behavior
具有自清洁行为的微图案热响应纳米复合水凝胶表面
  • 批准号:
    0854462
  • 财政年份:
    2009
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant

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Portable Thermophotonic Biosensor Development for in-vivo Blood Glucose Monitoring
用于体内血糖监测的便携式热光子生物传感器的开发
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Real-time biosensor for continuous in vivo detection of glucose**
用于连续体内葡萄糖检测的实时生物传感器**
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A Self-Cleaning Membrane to Extend the Lifetime of an Implanted Glucose Biosensor
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SBIR 第一阶段:使用个人血糖仪监测茶碱的新型生物传感器
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A Self-Cleaning Membrane to Extend the Lifetime of an Implanted Glucose Biosensor
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