I-Corps: Novel Biodegradable Metals and Biomimetic Interfaces with Enhanced Strength and Bioactivity

I-Corps：新型可生物降解金属和仿生界面，具有增强的强度和生物活性

• 批准号: 1840332
• 负责人: Huinan Liu
• 金额: $ 5万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1840332&HistoricalAwards=false
• 关键词: Corps; Novel; Biodegradable; Metals; Biomimetic

The broader impact/commercial potential of this I-Corps project on healthcare, quality of life, and the medical device industry is tremendous. The novel technology and advancement of biodegradable metals and biomimetic interfaces will lead to next-generation medical devices and implants that promote tissue healing and eliminate secondary surgeries for implant removal. This will improve quality of life for patients who need medical implants to support bones and tissue damaged by disease or trauma, and reduce overall healthcare costs. The project will build the foundation for commercializing biodegradable metallic implants and devices, which, in turn, will increase the competitiveness of U.S. companies in the medical device industry. The products resulting from this project will reduce pain and complications, eliminate secondary surgeries, and accelerate healing and recovery for patients who need medical implants due to trauma or disease.This I-Corps project will advance technology that eliminates the drawbacks of the non-degradable medical alloys on the market today. Magnesium (Mg) based alloys are a novel class of biodegradable metallic materials that have attractive mechanical and biological properties for a wide range of medical implant applications, such as orthopedic, spinal, dental, and craniofacial implants. The key challenge in commercializing Mg-based alloys for medical implant applications lies in controlling the degradation rate. NSF support has contributed to a novel class of biocompatible Mg alloys along with biomimetic surface treatment to provide tunable degradation rates, desirable bioactivity, and excellent mechanical strength for supporting faster healing and regeneration of damaged tissues. This novel solution contains non-toxic natural elements that induce healing and reduce inflammation, departed from traditional alloy design. The I-Corps project will transform this technology to commercially viable products that will benefit the customers in need.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目对医疗保健、生活质量和医疗器械行业的更广泛影响/商业潜力是巨大的。可生物降解金属和仿生界面的新技术和进步将催生下一代医疗设备和植入物，促进组织愈合并消除植入物移除的二次手术。这将提高需要医疗植入物来支持因疾病或创伤受损的骨骼和组织的患者的生活质量，并降低总体医疗费用。该项目将为可生物降解金属植入物和设备的商业化奠定基础，从而提高美国公司在医疗器械行业的竞争力。该项目产生的产品将减少疼痛和并发症，消除二次手术，并加速因创伤或疾病而需要医疗植入物的患者的愈合和康复。I-Corps 项目将推进技术，消除当今市场上不可降解医用合金的缺点。镁 (Mg) 基合金是一类新型的可生物降解金属材料，具有有吸引力的机械和生物性能，适用于各种医疗植入物应用，例如骨科、脊柱、牙科和颅面植入物。将镁基合金用于医疗植入应用商业化的关键挑战在于控制降解率。 NSF 的支持有助于开发出一类新型生物相容性镁合金以及仿生表面处理，以提供可调节的降解速率、理想的生物活性和出色的机械强度，以支持受损组织更快的愈合和再生。这种新颖的解决方案含有无毒的天然元素，可以促进愈合并减少炎症，与传统的合金设计不同。 I-Corps 项目将把这项技术转化为商业上可行的产品，使有需要的客户受益。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。