MRI: Track 1 Acquisition of a Single-Crystal X-ray Diffractometer to Support Primarily Undergraduate Research in the Greater Susquehanna Valley

该奖项由主要研究仪器（MRI）和化学研究仪器（CRIF）项目共同支持。萨斯奎哈纳大学正在购买一个带密封管铜x射线源的衍射仪，一个电荷集成像素阵列探测器和一个液氮燃料的低温冷却装置，以支持威廉·多尔蒂（萨斯奎哈纳大学）、布莱恩·史密斯（巴克内尔大学）和两所大学的同事的研究。一般来说，x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机和无机化学，催化和材料化学。该仪器是这些机构包括化学和生物化学在内的多学科本科生和研究生的教学、研究和研究训练的一个组成部分。该仪器将作为萨斯奎汉纳河谷地区的区域资源，使其他主要本科院校的师生受益，包括与莱康明学院、伊丽莎白镇学院和威尔克斯大学的合作。该奖项旨在加强各级的研究和教育。该仪器的研究重点是小分子、共价有机框架（COFs）、纳米材料和超分子结构的合成、结构测定和应用。支持的研究将促进对合成途径的基本理解，帮助开发新的治疗平台和显像剂，为晶体生长的各种机制提供见解，并探索小分子设计与最终电子和结构特性之间的关系。正在研究的化合物在材料科学方面有应用，包括开发新的催化剂、专门过滤、生产更高效的光伏设备和制造选择性化学传感器。其他拟议的项目在医学领域也有应用，通过产生具有抗菌，抗炎和抗癌特性的复合物，成像的有效造影剂，以及改进药物配方中的结晶方法。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) programs. Susquehanna University is acquiring a diffractometer with a sealed-tube copper X-ray source, a charge-integrated pixel array detector and a liquid-nitrogen-fueled low temperature cooling device to support the research of William Dougherty Jr. (Susquehanna University), Brian Smith (Bucknell University), and colleagues at both institutions. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact many areas, including organic and inorganic chemistry, catalysis, and materials chemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate master’s students in multiple disciplines including chemistry and biochemistry at these institutions. The instrument will serve as a regional resource for the greater Susquehanna valley benefiting faculty and students at additional primarily undergraduate institutions including collaborative efforts with Lycoming College, Elizabethtown College, and Wilkes University. The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on the synthesis, structure determination, and applications of small molecules, covalent organic frameworks (COFs), nanomaterials, and supramolecular structures. The supported research will advance the fundamental understanding of synthetic pathways, aid in the development of new therapeutic platforms and imaging agents, provide insight into the varied mechanisms of crystal growth and explore the relationship between small-molecule design and the resulting electronic and structural properties. The compounds under investigation have applications in material science including the development of new catalysts, specialized filtration, the generation of more efficient photovoltaic devices and the creation of selective chemical sensors. Other proposed projects have applications in the field of medicine through the generation of complexes with anti-bacterial, anti-inflammatory and anti-cancer properties, efficient contrast agents for imaging, and improving crystallization approaches in pharmaceutical formulation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.