MRI: Track 1 Acquisition of a Single-Crystal X-ray Diffractometer to Support Primarily Undergraduate Research in the Greater Susquehanna Valley

该奖项由主要研究仪器（MRI）和化学研究仪器（CRIF）计划共同支持。萨斯奎汉纳大学正在购买一台带有密封管铜X射线源、电荷集成像素阵列探测器和液氮燃料低温冷却设备的衍射仪，以支持William Doughnut Jr.的研究。（萨斯奎汉纳大学），布赖恩史密斯（巴克内尔大学），以及在这两个机构的同事。一般来说，X射线衍射仪允许准确和精确地测量分子的完整三维结构，包括键距和角度，并提供关于分子相对于相邻分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机和无机化学，催化和材料化学。 该仪器是教学的一个组成部分，以及在这些机构的本科生和研究生硕士生在多个学科，包括化学和生物化学的研究和研究培训。该仪器将作为一个区域资源，为更大的萨斯奎汉纳山谷受益教师和学生在其他主要是本科院校，包括与莱康明学院，伊丽莎白敦学院和威尔克斯大学的合作努力。该奖项旨在加强各级的研究和教育。该仪器的研究重点是小分子，共价有机框架（COFs），纳米材料和超分子结构的合成，结构测定和应用。支持的研究将推进对合成途径的基本理解，帮助开发新的治疗平台和成像剂，深入了解晶体生长的各种机制，并探索小分子设计与所得电子和结构性质之间的关系。正在研究的化合物在材料科学中有应用，包括开发新的催化剂，专门的过滤，产生更有效的光伏器件和创建选择性化学传感器。此外，还通过抗菌、抗炎、抗癌等复合物的合成、高效造影剂的开发、药物制剂结晶方法的改进等，在医药领域得到了应用。该奖项体现了NSF的法定使命，通过对基金会的学术价值和更广泛的影响力评价标准进行评估，被认为是值得支持的。

This award is jointly supported by the Major Research Instrumentation (MRI) and the Chemistry Research Instrumentation (CRIF) programs. Susquehanna University is acquiring a diffractometer with a sealed-tube copper X-ray source, a charge-integrated pixel array detector and a liquid-nitrogen-fueled low temperature cooling device to support the research of William Dougherty Jr. (Susquehanna University), Brian Smith (Bucknell University), and colleagues at both institutions. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact many areas, including organic and inorganic chemistry, catalysis, and materials chemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate master’s students in multiple disciplines including chemistry and biochemistry at these institutions. The instrument will serve as a regional resource for the greater Susquehanna valley benefiting faculty and students at additional primarily undergraduate institutions including collaborative efforts with Lycoming College, Elizabethtown College, and Wilkes University. The award is aimed at enhancing research and education at all levels. Research enabled by the instrument is focused on the synthesis, structure determination, and applications of small molecules, covalent organic frameworks (COFs), nanomaterials, and supramolecular structures. The supported research will advance the fundamental understanding of synthetic pathways, aid in the development of new therapeutic platforms and imaging agents, provide insight into the varied mechanisms of crystal growth and explore the relationship between small-molecule design and the resulting electronic and structural properties. The compounds under investigation have applications in material science including the development of new catalysts, specialized filtration, the generation of more efficient photovoltaic devices and the creation of selective chemical sensors. Other proposed projects have applications in the field of medicine through the generation of complexes with anti-bacterial, anti-inflammatory and anti-cancer properties, efficient contrast agents for imaging, and improving crystallization approaches in pharmaceutical formulation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.