Polydepsipeptoids - a novel biomaterials plattform

聚酯和聚酯酰胺（也称为聚缩酚肽）是非常成功的生物材料，用于外科缝合线，生物医学植入物，药物输送系统，以及可生物降解的塑料，如饮料杯。然而，它仍然是一个显着的需求，新的生物材料具有广泛的可调的理化特性和降解曲线。在这里，我们提出了一类新的聚合物，N-取代的聚酯酰胺（polydepsipeptoids），这是通过一个模块化的和容易的合成共聚路线访问的合成。这种新型材料有望将聚酯和类多肽的有利性能联合收割机结合起来。聚合物的性能将通过共聚而系统地改变。的热性能和降解曲线依赖于pH值的新材料将详细的特点。最后，我们将为非织造纤维垫和纤维的制备提供原理验证。在未来，这种新型生物材料有望在制备具有定制和增强性能的生物可降解纤维、薄膜、支架或药物递送系统方面具有很高的价值。

Polyesters and polyesteramides (also called polydepsipeptides) are highly successful biomaterials that are employed in surgical sutures, biomedical implants, drug delivery systems but also biodegradable plastics such as cups for beverages. Nevertheless, it remains a significant demand for new biomaterials with widely tuneable physicochemical characteristics and degradation profile. Here, we propose the synthesis of a novel class of polymers, N-substituted polyesteramides (polydepsipeptoids), which are accessible via a modular and facile synthetic copolymerization route. The novel materials are expected to combine the favourable properties of polyester and polypeptoids. The polymer properties will be systematically varied by copolymerization. The thermal properties and the degradation profile in dependence of the pH value of the novel materials will be characterized in detail. Finally, we will provide proof-of-principle for the preparation of non-woven fibre mats and fibres. In the future, the novel biomaterials are expected to be highly valuable for the preparation of biodegradable fibres, films, scaffolds or drug delivery systems with tailored and enhanced properties.