Polydepsipeptoids - a novel biomaterials plattform

聚酯和聚酯酰胺（也被称为多肽）是非常成功的生物材料，用于外科缝合线，生物医学植入物，药物输送系统，以及生物可降解塑料，如饮料杯。然而，对具有广泛可调物理化学特性和降解特征的新型生物材料的需求仍然很大。在这里，我们提出了一种新型聚合物的合成，n取代聚酯酰胺（聚depsipeptoids），它可以通过模块化和易于合成的共聚途径获得。这种新型材料有望结合聚酯和多肽的优良性能。共聚反应会系统地改变聚合物的性能。新材料的热性能和降解曲线与pH值的关系将被详细表征。最后，我们将为非织造纤维垫和纤维的制备提供原理证明。在未来，这种新型生物材料有望在制备具有定制和增强性能的可生物降解纤维、薄膜、支架或药物输送系统方面具有很高的价值。

Polyesters and polyesteramides (also called polydepsipeptides) are highly successful biomaterials that are employed in surgical sutures, biomedical implants, drug delivery systems but also biodegradable plastics such as cups for beverages. Nevertheless, it remains a significant demand for new biomaterials with widely tuneable physicochemical characteristics and degradation profile. Here, we propose the synthesis of a novel class of polymers, N-substituted polyesteramides (polydepsipeptoids), which are accessible via a modular and facile synthetic copolymerization route. The novel materials are expected to combine the favourable properties of polyester and polypeptoids. The polymer properties will be systematically varied by copolymerization. The thermal properties and the degradation profile in dependence of the pH value of the novel materials will be characterized in detail. Finally, we will provide proof-of-principle for the preparation of non-woven fibre mats and fibres. In the future, the novel biomaterials are expected to be highly valuable for the preparation of biodegradable fibres, films, scaffolds or drug delivery systems with tailored and enhanced properties.