Polydepsipeptoids - a novel biomaterials plattform

聚酯和聚酯酰胺(也称为多肽)是非常成功的生物材料，不仅用于外科缝合线、生物医学植入物、药物输送系统，还用于可生物降解的塑料，如饮料的杯子。然而，它仍然是一个重要的需求，新的生物材料具有广泛可调的物理化学特性和降解曲线。在这里，我们建议合成一类新的聚合物，N-取代聚酯酰胺(聚多肽)，可以通过模块化和简单的合成共聚路线获得。这种新型材料有望结合聚酯和多肽的良好性能。通过共聚反应，聚合物的性质将发生系统的变化。新材料的热性能和随pH值变化的降解曲线将被详细表征。最后，我们将为无纺布纤维垫和纤维的制备提供原则证明。在未来，这种新型生物材料有望在制备具有定制和增强性能的可生物降解纤维、薄膜、支架或药物输送系统方面具有很高的价值。

Polyesters and polyesteramides (also called polydepsipeptides) are highly successful biomaterials that are employed in surgical sutures, biomedical implants, drug delivery systems but also biodegradable plastics such as cups for beverages. Nevertheless, it remains a significant demand for new biomaterials with widely tuneable physicochemical characteristics and degradation profile. Here, we propose the synthesis of a novel class of polymers, N-substituted polyesteramides (polydepsipeptoids), which are accessible via a modular and facile synthetic copolymerization route. The novel materials are expected to combine the favourable properties of polyester and polypeptoids. The polymer properties will be systematically varied by copolymerization. The thermal properties and the degradation profile in dependence of the pH value of the novel materials will be characterized in detail. Finally, we will provide proof-of-principle for the preparation of non-woven fibre mats and fibres. In the future, the novel biomaterials are expected to be highly valuable for the preparation of biodegradable fibres, films, scaffolds or drug delivery systems with tailored and enhanced properties.