I-Corps: Portable airbrush-based device to treat hemorrhage and promote accelerated healing of traumatic wounds

这个i-Corps项目的更广泛的影响/商业潜力是开发一种便携式技术，旨在止住严重出血并提供长期全面的伤口护理。在美国，30%到40%的平民创伤死亡是由出血造成的，这是战场上死亡的主要原因。目前，没有一种用于治疗出血的技术被批准长期使用。这项拟议的技术旨在密封和治愈创伤性伤口，而不需要缝合，并可用于治疗枪击受害者和发生点的其他创伤性伤口。此外，它可以由战争前线的非专家人员操作，也可以由文职急救人员操作，并可能提供全面的长期伤口护理。随着枪支暴力的增加，在急诊室人满为患的大流行情况下，以及在世界上获得医疗服务有限的偏远地区，这一点尤其重要。此外，拟议的技术可用于治疗烧伤或压疮的大面积，该技术也可用于治疗受伤的动物。这个i-Corps项目是基于开发一种治疗出血和促进创伤伤口加速愈合的医疗设备。这项拟议的技术使用由便携式二氧化碳气瓶驱动的喷雾器来推动含有悬浮纳米姜黄、抗微生物制剂和止痛剂的丙酮聚合物溶液。该溶剂在半空中蒸发，直接在伤口区域沉积生物活性和可生物吸收的纳米复合材料，以现场止血，加速伤口愈合，并提供长期的伤口护理。此外，该设备还避免了急救人员可能接触患者血液的情况。该技术的止血和加速伤口愈合的性能已经用小鼠模型进行了评估。此外，该溶液完全由FDA批准用于人类长期使用的成分组成，这可能代表着全面伤口护理方面的一步。拟议的设备可以止血，预防感染，促进伤口加速愈合，并帮助拯救全球生命。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of a portable technology designed to arrest severe bleeding and provide long-term comprehensive wound care. In the United States, thirty to forty percent of civilian deaths by trauma are the result of hemorrhage and it is the main cause of death on the battlefield. Currently, none of the technologies used to address hemorrhage are approved for long-term use. The proposed technology is designed to seal and heal traumatic wounds without the need for stitches, and may be used to treat gunshot victims and other traumatic wounds at the point of occurrence. In addition, it may be operated by a non-specialist on the war front or by civilian first responders, and may provide comprehensive long-term wound care. This is particularly important with the rise in gun violence, in pandemic-like situations where emergency rooms are overwhelmed, and in remote regions of the world where access to medical care is limited. In addition, the proposed technology may be used to treat large surface areas encountered in burns or bedsores, and the technology also may be developed to treat wounded animals.This I-Corps project is based on the development of a medical device to treat hemorrhage and promote accelerated healing of traumatic wounds. The proposed technology uses an airbrush powered by a portable CO2 cylinder to propel a polymer solution in acetone with suspended nano-turmeric, an anti-microbial agent, and an analgesic. The solvent evaporates midair to directly deposit a bioactive and bioresorbable nanocomposite on the wound area to arrest hemorrhage on the spot, provide accelerated wound healing, and long-term wound care. In addition, the device avoids the potential exposure of first responders to patient blood. The bleed arrest and accelerated wound healing properties of the technology have been evaluated with mouse models. Further, the solution is exclusively composed of ingredients that are FDA approved for long-term use in humans, which may represent a step forward in comprehensive wound care. The proposed device may arrest hemorrhage, prevent infection, promote accelerated wound healing, and help save lives globally.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.