I-Corps: Portable airbrush-based device to treat hemorrhage and promote accelerated healing of traumatic wounds

I-Corps项目更广泛的影响/商业潜力是开发一种便携式技术，旨在阻止严重出血并提供长期全面的伤口护理。在美国，百分之三十到四十的平民死于创伤是由于出血，这是战场上死亡的主要原因。目前，没有一种用于治疗出血的技术被批准用于长期使用。该技术旨在密封和愈合创伤伤口，而不需要缝合，并可用于治疗枪伤受害者和其他创伤的发生点。此外，它可以由战争前线的非专业人员或平民急救人员操作，并可以提供全面的长期伤口护理。随着枪支暴力的增加，在类似大流行病的情况下，急诊室人满为患，以及在世界上获得医疗服务的机会有限的偏远地区，这一点尤为重要。此外，所提出的技术可用于治疗烧伤或褥疮中遇到的大表面积，并且该技术也可用于治疗受伤的动物。这个I-Corps项目的基础是开发一种治疗出血和促进创伤性伤口加速愈合的医疗设备。这项拟议中的技术使用一种喷枪，由便携式二氧化碳气缸驱动，在丙酮中喷射悬浮的纳米姜黄（一种抗菌剂和止痛药）聚合物溶液。溶剂在空气中蒸发，直接将生物活性和生物可吸收的纳米复合材料沉积在伤口区域，以当场止血，加速伤口愈合，并提供长期伤口护理。此外，该装置避免了急救人员接触病人血液的潜在风险。该技术的止血和加速伤口愈合特性已经用小鼠模型进行了评估。此外，该解决方案完全由FDA批准的人类长期使用的成分组成，这可能代表着全面伤口护理的一步。该装置可以阻止出血，预防感染，促进伤口加速愈合，并帮助拯救全球生命。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of a portable technology designed to arrest severe bleeding and provide long-term comprehensive wound care. In the United States, thirty to forty percent of civilian deaths by trauma are the result of hemorrhage and it is the main cause of death on the battlefield. Currently, none of the technologies used to address hemorrhage are approved for long-term use. The proposed technology is designed to seal and heal traumatic wounds without the need for stitches, and may be used to treat gunshot victims and other traumatic wounds at the point of occurrence. In addition, it may be operated by a non-specialist on the war front or by civilian first responders, and may provide comprehensive long-term wound care. This is particularly important with the rise in gun violence, in pandemic-like situations where emergency rooms are overwhelmed, and in remote regions of the world where access to medical care is limited. In addition, the proposed technology may be used to treat large surface areas encountered in burns or bedsores, and the technology also may be developed to treat wounded animals.This I-Corps project is based on the development of a medical device to treat hemorrhage and promote accelerated healing of traumatic wounds. The proposed technology uses an airbrush powered by a portable CO2 cylinder to propel a polymer solution in acetone with suspended nano-turmeric, an anti-microbial agent, and an analgesic. The solvent evaporates midair to directly deposit a bioactive and bioresorbable nanocomposite on the wound area to arrest hemorrhage on the spot, provide accelerated wound healing, and long-term wound care. In addition, the device avoids the potential exposure of first responders to patient blood. The bleed arrest and accelerated wound healing properties of the technology have been evaluated with mouse models. Further, the solution is exclusively composed of ingredients that are FDA approved for long-term use in humans, which may represent a step forward in comprehensive wound care. The proposed device may arrest hemorrhage, prevent infection, promote accelerated wound healing, and help save lives globally.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.