Magnetic surfaces for the controlled manipulation of superparamagnetic microbeads

用于控制操纵超顺磁性微珠的磁性表面

• 批准号: 258304063
• 负责人: Professor Dr.-Ing. Jeffrey McCord
• 金额: --
• 依托单位: Arbeitsgruppe Nanoscale Magnetic Materials - Magnetic Domains
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/258304063?language=en
• 关键词: Magnetic; surfaces; controlled; manipulation; superparamagnetic

The manipulation of superparamagnetic microbeads withfunctionalized surfaces as labels for single-molecule studies, for cellmanipulation, and detection of chemical or biological species in liquidenvironments are in the focus of the research project. Within theproject the fundamentals for the movement of superparamagneticbeads on functionalized magnetic surfaces will be explored. As abasis for the manipulation of beads, micro-lithographically patternedmagnetic surfaces in the form of array elements creating aninterconnecting magnetic network will be investigated. The transportof individual beads is performed by micro-magnetic objects such ascharged magnetic domain walls or switchable magnetizationstructures. Within the project the controlled movement of microbeadsalong magnetic structures with the help of variable multi-axismagnetic field protocols will be investigated. Different approaches arebeing explored for the transport of superparamagnetic particles inliquid suspensions. Moreover, hydrodynamic effects will be utilized byapplying temporal and angle varying magnetic fields with differentfrequency components. The lateral distribution of the magneticpatterns and the corresponding motion of the microbeads areanalyzed directly by complementary in-situ magnetic and bright-fieldoptical microscopy. The investigations will be supported by in depthsimulations. The research will open up new ways to laterallymanipulate marked biological objects, to facilitate a controlledmovement of particles in microfluidic environments over substantialdistances, and in that way provide the foundations for themanipulation and separation of biological objects in integratedflowless lab-on-chip devices.

超顺磁性微珠的操作与功能化的表面作为单分子研究的标记，细胞操作，和检测液体环境中的化学或生物物种是研究项目的重点。在这个项目中，将探索超顺磁性微珠在功能化磁性表面上运动的基本原理。作为操纵珠子的基础，将研究以阵列元件的形式形成互连磁网络的微光刻图案化磁表面。单个微珠的运输是由微磁性物体如带电磁畴壁或可切换的磁化结构来完成的。在该项目中，将研究借助可变多轴磁场协议控制微珠沿磁性结构的运动。人们正在探索不同的方法来研究超顺磁性粒子在悬浮液中的输运。此外，将通过施加具有不同频率分量的时间和角度变化的磁场来利用流体动力学效应。利用互补原位磁显微镜和明场光学显微镜直接分析了磁图案的横向分布和相应的微珠运动。这些调查将得到深度模拟的支持。这项研究将开辟新的方法来横向操纵标记的生物物体，促进微流体环境中粒子在相当长的距离内的受控运动，并以这种方式为集成无流实验室芯片设备中的生物物体的操纵和分离提供基础。