I-Corps: Platform for Improving Biolistic Delivery to Plant Cells
I-Corps:改善植物细胞生物射弹递送的平台
基本信息
- 批准号:2346805
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2024
- 资助国家:美国
- 起止时间:2024-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this I-Corps project is the development of a new device that can help broadly advance gene functional studies, crop breeding and the development of novel plant-based products. The technology could produce positive impacts in sectors including agriculture, energy, and environmental science. The improved efficiency of DNA and protein delivery into plant cells can potentially increase the production of genetically modified crops without transgene (foreign gene(s)), providing a product that is much less restricted by federal regulations globally. The technology could help address food insecurity in addition to energy and environmental challenges by helping produce more and better energy related biocrops.This I-Corps project is based on the development of a platform that can improve the current biolistic delivery system in terms of efficacy and consistency. The interdisciplinary approach could help build a high-impact technology platform for the field of plant gene editing. The original biolistic device, gene gun, was designed more than 30 years ago. This technology is a straightforward attachment to the current device, which can alter the flow and trajectory of the particles towards the tissue. By carefully designing the geometry of our device, we can significantly increase the delivery efficacy by optimizing the aerodynamic flow and creating more focused and even pressure on the plant tissue. Our preliminary data has shown 20x increase in DNA delivery efficiency to onion epidermis cells. In addition, our design can be quickly modified using three-dimensional printing technology to accommodate plant tissues of different species with different geometries. Furthermore, this device has shed light into the poorly understood biolistic system, enabling further research into how the gene gun works could improve understanding of the entire biolistic system.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个I-Corps项目的更广泛的影响/商业潜力是开发一种新设备,可以帮助广泛推进基因功能研究,作物育种和新型植物产品的开发。该技术可以在农业、能源和环境科学等部门产生积极影响。DNA和蛋白质递送到植物细胞中的效率的提高可以潜在地增加没有转基因(外源基因)的转基因作物的产量,从而提供在全球范围内受联邦法规限制少得多的产品。 该技术可以通过帮助生产更多更好的能源相关生物作物来帮助解决粮食不安全以及能源和环境挑战。该I-Corps项目基于开发一个平台,该平台可以改善当前生物射弹输送系统的功效和一致性。这种跨学科的方法可以帮助为植物基因编辑领域建立一个高影响力的技术平台。 最初的生物射弹装置基因枪是30多年前设计的。该技术是对当前设备的直接连接,其可以改变颗粒朝向组织的流动和轨迹。通过仔细设计我们设备的几何形状,我们可以通过优化空气动力学流动并在植物组织上产生更集中和均匀的压力来显著提高输送效率。我们的初步数据显示,洋葱表皮细胞的DNA递送效率提高了20倍。此外,我们的设计可以使用三维打印技术快速修改,以适应不同物种的植物组织具有不同的几何形状。此外,该装置还揭示了人们对基因枪系统知之甚少的情况,使人们能够进一步研究基因枪的工作原理,从而提高对整个基因枪系统的理解。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Shan Jiang其他文献
A new species of Omeisaurus (Dinosauria: Sauropoda) from the Middle Jurassic of Yunyang, Chongqing, China
中国重庆云阳中侏罗世峨眉龙一新种(恐龙亚目:蜥脚类)
- DOI:
10.1080/08912963.2020.1743286 - 发表时间:
2020-04 - 期刊:
- 影响因子:1.4
- 作者:
Chao Tan;Ming Xiao;Hui Dai;Xu-Feng Hu;Ning Li;Qing-Yu Ma;Zhao-Ying Wei;Hai-Dong Yu;Can Xiong;Guang-Zhao Peng;Shan Jiang;Xin-Xin Ren;Hai-Lu You - 通讯作者:
Hai-Lu You
Nitrogen isotopic analysis of nitrate in aquatic environment using cadmium-hydroxylamine hydrochloride reduction
使用镉-羟胺盐酸盐还原法分析水生环境中硝酸盐的氮同位素
- DOI:
10.1002/rcm.8804 - 发表时间:
2020 - 期刊:
- 影响因子:2
- 作者:
Jie Jin;Shan Jiang;Jing Zhang - 通讯作者:
Jing Zhang
Effect of Crystal Chemistry Properties on the Distribution Characteristics of H2O and Na+ in Na-Montmorillonite Interlayer Space: Molecular Dynamics Simulation Study
晶体化学性质对Na-蒙脱石层间空间中H2O和Na分布特征的影响:分子动力学模拟研究
- DOI:
10.3390/min10020162 - 发表时间:
2020-02 - 期刊:
- 影响因子:2.5
- 作者:
Jun Qiu;Dongliang Liu;Shan Jiang;Guowei Chen;Yueting Wang;Guoqing Li;Geng Yao;Peng Wu;Xiangnan Zhu;Guifang Wang;Xianjun Lyu - 通讯作者:
Xianjun Lyu
Genetic variation and phylogeographic structure of Laodelphax striatellus in China based on microsatellite markers
基于微卫星标记的中国灰飞虱遗传变异及系统发育地理结构
- DOI:
10.1111/jen.12847 - 发表时间:
2020-12 - 期刊:
- 影响因子:1.9
- 作者:
Shan Jiang;Kexin Zhu;Lei Han;Chen Chen;Mingming Wang;Xingya Wang - 通讯作者:
Xingya Wang
Dynamic impact of social network on knowledge contribution loafing in mobile collaboration: a hidden Markov model
社交网络对移动协作中知识贡献游移的动态影响:隐马尔可夫模型
- DOI:
10.1108/jkm-10-2018-0641 - 发表时间:
2019-11 - 期刊:
- 影响因子:7
- 作者:
Shan Jiang;Xi Zhang;Yihang Cheng;Dongming Xu;Patricia Ordóñez de Pablos;Xuyan Wang - 通讯作者:
Xuyan Wang
Shan Jiang的其他文献
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{{ truncateString('Shan Jiang', 18)}}的其他基金
PFI-TT: Creating highly efficient waterborne self-sanitizing coatings that incorporate novel additives
PFI-TT:创建含有新型添加剂的高效水性自消毒涂料
- 批准号:
2213976 - 财政年份:2022
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
I-Corps: Improved Coating Properties Using Janus Particle Additives
I-Corps:使用 Janus 颗粒添加剂改善涂层性能
- 批准号:
2110172 - 财政年份:2021
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
IGE: Learning Communities of Graduates for Advancing Professional Skills (GAPS): Integrate Professional Skill Training with Thesis Research
IGE:提升专业技能的毕业生学习社区(GAPS):将专业技能培训与论文研究相结合
- 批准号:
1954946 - 财政年份:2020
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
Symposium on "Surface, Interface, and Coating Materials" Symposium, 256th American Chemical Society (ACS) National Meeting; Boston, Massachusetts; 19-23 August 2018
第256届美国化学会(ACS)全国会议“表面、界面和涂层材料”研讨会;
- 批准号:
1819515 - 财政年份:2018
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
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