CAREER: Quorum enhanced sustainable treatment of nitrogen (QuEST-N)

职业:群体强化可持续氮处理 (QuEST-N)

基本信息

  • 批准号:
    2349328
  • 负责人:
  • 金额:
    $ 54.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-10-01 至 2027-07-31
  • 项目状态:
    未结题

项目摘要

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2).Environmental engineers have used microorganisms over a century to treat wastewater and protect public health. Biological wastewater treatment (WWT) also plays a critical role in ecosystem and environmental protection including the use of nitrifying and denitrifying bacteria to remove and convert excess nitrogen from wastewater to harmless nitrogen (N2) gas. Advances in environmental metagenomics are providing more detailed and in-depth information about microbial communities in WWT systems. Yet, environmental engineers and wastewater practitioners lack strategies and tools to leverage this new information to control the structure, composition, functional diversity, and metabolic pathways of nitrifying and denitrifying bacterial communities in WWT systems. The overarching goal of this CAREER proposal is to harness various forms of microbial communication signals, commonly referred to as quorum sensing (QS) molecules, to advance the design and operations of more efficient and sustainable biofilm reactors for nitrogen removal. The successful completion of this project will benefit society through the generation of new fundamental knowledge to advance the development and implementation of next generation biological nitrogen removal (BNR) processes in wastewater treatment plants (WWTPs) and water resource recovery facilities (WRRFs). Further benefits to society will be achieved through student education and training including the mentoring of a post-doctoral fellow, a graduate student, and three undergraduate students at Howard University.Advances in environmental microbiology, microbial ecology, and environmental biotechnology are providing unprecedented opportunities to design and build next generation biofilm reactors for the simultaneous removal of excess nutrients (nitrogen and phosphorus) from wastewater. Biofilm reactors are enabling WWTPs and WRRFs to harness slow growing microorganisms that are advantageous to BNR processes including anaerobic ammonium oxidizers (anammox) and denitrifying anaerobic methane oxidizers (DAMO). However, the design and operation of next generation biofilm reactors for BNR will require the control of the biofilm microbial ecology to achieve more efficient and cost-effective nitrogen removal from wastewater. The overarching goal of this CAREER project is to explore the use of quorum sensing (QS) to control and manipulate the microbial ecology of bacterial biofilms used in BNR reactors. QS involves the generation and release of signaling molecules known as autoinducers that enable bacterial communities to coordinate their behavior including the formation of biofilms. The guiding hypotheses of this research are that the presence of autoinducers changes the activity of nitrogen cycling bacteria and QS can be used to alter which organisms colonize a biofilm. The specific objectives of the proposed research are to: (1) Test the effect of autoinducers in cultures enriched for nitrogen cycling bacteria; (2) Evaluate the effect of autoinducers in nitrogen cycling bacteria in more complex biofilm communities; (3) Develop a biofilm model that incorporates QS; and (4) Evaluate a control strategy that uses autoinducer molecules in a membrane aerated biofilm reactor. The successful completion of this project has the potential for transformative impact through the generation of fundamental knowledge to advance the development and deployment of the new process of quorum enhanced sustainable treatment of nitrogen (QuEST-N) within WWTPs and WRRFs. To achieve the educational and training goals of this CAREER project, the Principal Investigator will leverage her ongoing collaboration with the Water Environment Federation (WEF) to 1) add a research training component to the InFLOW (Increasing Opportunities in Water) program at Howard University and 2) expand the program to other minority serving institutions (MSI) to advance diversity in STEM education and broaden participation in the water industry workforce.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该奖项全部或部分由2021年美国救援计划法案(公法117-2)资助。环境工程师在世纪以来一直使用微生物来处理废水,保护公众健康。生物废水处理(WWT)在生态系统和环境保护中也起着关键作用,包括使用硝化和反硝化细菌来去除废水中的过量氮并将其转化为无害的氮(N2)气体。环境宏基因组学的进展正在提供有关WWT系统中微生物群落的更详细和深入的信息。然而,环境工程师和废水从业者缺乏策略和工具来利用这些新信息来控制污水处理系统中硝化和反硝化细菌群落的结构,组成,功能多样性和代谢途径。该CAREER提案的总体目标是利用各种形式的微生物通信信号,通常称为群体感应(QS)分子,以推进更有效和可持续的生物膜反应器的设计和操作,用于脱氮。该项目的成功完成将通过产生新的基础知识来促进污水处理厂(WWTPs)和水资源回收设施(WRRF)中下一代生物脱氮(BNR)工艺的开发和实施,从而造福社会。通过学生教育和培训,包括指导霍华德大学的一名博士后研究员、一名研究生和三名本科生,将进一步造福社会。环境生物技术为设计和建造下一代生物膜反应器提供了前所未有的机会,(氮和磷)。生物膜反应器使污水处理厂和WRRF能够利用有利于BNR工艺的缓慢生长的微生物,包括厌氧氨氧化剂(anammox)和厌氧甲烷氧化剂(DAMO)。然而,下一代生物膜反应器的设计和运行将需要控制生物膜微生物生态,以实现更有效和更具成本效益的污水脱氮。这个CAREER项目的首要目标是探索使用群体感应(QS)来控制和操纵BNR反应器中使用的细菌生物膜的微生物生态。QS涉及称为自诱导物的信号分子的产生和释放,其使细菌群落能够协调其行为,包括生物膜的形成。本研究的指导假设是,自诱导剂的存在改变了氮循环细菌的活性,而QS可用于改变哪些生物体定植在生物膜上。拟议研究的具体目标是:(1)测试自诱导物在富含氮循环细菌的培养物中的作用;(2)评估自诱导物在更复杂的生物膜群落中的氮循环细菌中的作用;(3)开发结合QS的生物膜模型;(4)评估在膜曝气生物膜反应器中使用自诱导物分子的控制策略。该项目的成功完成具有潜在的变革性影响,通过产生基础知识,以推动在污水处理厂和WRRF内开发和部署新的法定人数增强可持续氮处理(QuEST-N)。为了实现这个职业生涯项目的教育和培训目标,首席研究员将利用她与水环境联合会(WEF)的持续合作,1)在InFLOW中增加研究培训部分(增加水的机会)计划在霍华德大学和2)扩大该计划的其他少数民族服务机构(MSI)该奖项反映了NSF的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(0)
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Jeseth Delgado Vela其他文献

Metagenomic Analysis of the Antibiotic Resistance Risk between an Aerobic and Anaerobic Membrane Bioreactor
好氧和厌氧膜生物反应器之间抗生素耐药性风险的宏基因组分析
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Phillip Wang;Ali Zarei;Jeseth Delgado Vela;Adam L. Smith
  • 通讯作者:
    Adam L. Smith
Elucidating the impact of microbial community biodiversity on pharmaceutical biotransformation during wastewater treatment
阐明废水处理过程中微生物群落生物多样性对药物生物转化的影响
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    L. Stadler;Jeseth Delgado Vela;Sunit Jain;G. Dick;N. Love
  • 通讯作者:
    N. Love

Jeseth Delgado Vela的其他文献

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{{ truncateString('Jeseth Delgado Vela', 18)}}的其他基金

Collaborative Research: URoL:ASC: Determining the relationship between genes and ecosystem processes to improve biogeochemical models for nutrient management
合作研究:URoL:ASC:确定基因与生态系统过程之间的关系,以改进营养管理的生物地球化学模型
  • 批准号:
    2319124
  • 财政年份:
    2024
  • 资助金额:
    $ 54.55万
  • 项目类别:
    Standard Grant
CAREER: Quorum enhanced sustainable treatment of nitrogen (QuEST-N)
职业:群体强化可持续氮处理 (QuEST-N)
  • 批准号:
    2143410
  • 财政年份:
    2022
  • 资助金额:
    $ 54.55万
  • 项目类别:
    Continuing Grant
NSF/FDA SIR: Using Microbial Signaling Systems to Understand Relationship Between Microbial Growth an d Breast Implant Complications
NSF/FDA SIR:利用微生物信号系统了解微生物生长与乳房植入物并发症之间的关系
  • 批准号:
    2037572
  • 财政年份:
    2021
  • 资助金额:
    $ 54.55万
  • 项目类别:
    Standard Grant

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病原菌群体感应监管(policing quorum sensing)的生理生态机理及分子调控机制
  • 批准号:
    31570490
  • 批准年份:
    2015
  • 资助金额:
    63.0 万元
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  • 批准号:
    30370952
  • 批准年份:
    2003
  • 资助金额:
    21.0 万元
  • 项目类别:
    面上项目

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CAREER: The role of quorum sensing in a methane-oxidizing bacterial community
职业:群体感应在甲烷氧化细菌群落中的作用
  • 批准号:
    2339190
  • 财政年份:
    2024
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肠出血性大肠杆菌毒力基因的群体感应调控
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    10384063
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群体感应介导大流行霍乱弧菌和噬菌体 VP882 之间的通讯
  • 批准号:
    10601559
  • 财政年份:
    2023
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    $ 54.55万
  • 项目类别:
Elucidating the Interplay between the ComRS and the ComABCDE Quorum Sensing Circuitries in Streptococci
阐明链球菌中 ComRS 和 ComABCDE 群体感应电路之间的相互作用
  • 批准号:
    2316599
  • 财政年份:
    2023
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    $ 54.55万
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Optimising plant symbiotic bacteria through quorum-sensing and engineering biology approaches for delivery of climate-smart, sustainable nitrogen fer
通过群体感应和工程生物学方法优化植物共生细菌,以提供气候智能型、可持续的氮铁
  • 批准号:
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Modelling the effect of quorum sensing in fluid flow on biofilm function
模拟流体流动中群体感应对生物膜功能的影响
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    2857304
  • 财政年份:
    2023
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    $ 54.55万
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Quinolone and acyl-homoserine lactone quorum sensing in chronic P. aeruginosa infections
慢性铜绿假单胞菌感染中的喹诺酮和酰基高丝氨酸内酯群体感应
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A comprehensive investigation of Pseudomonas quorum sensing regulatory relationships and the consequences on quorum sensing inhibitors in complex communities
复杂群落中假单胞菌群体感应调控关系及其对群体感应抑制剂影响的全面研究
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    $ 54.55万
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Chemical tools to investigate chain-flipping in quorum signal synthases
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Characterization of the mechanisms underpinning quorum sensing progression in Pseudomonas aeruginosa
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