CAS: Catalysis with Cobalt Hydrides

CAS：氢化钴催化

• 批准号: 2349483
• 负责人: Hairong Guan
• 金额: $ 59.5万
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2349483&HistoricalAwards=false
• 关键词: CAS; Catalysis; Cobalt; Hydrides

With support from the Chemical Catalysis Program of the Division of Chemistry, Professor Hairong Guan and his group at the University of Cincinnati will examine the catalytic activities of cobalt hydrides. Catalysis plays an indispensable role in chemical synthesis for pharmaceutical, energy, and materials applications. Precious metals are often the metals of choice for designing catalysts. However, they are expensive, limited in supply, and sometimes difficult to remove from the products. In this project, Dr. Guan will focus on cobalt, an inexpensive and earth-abundant metal, to study the reactivity of molecules bearing cobalt-hydrogen bonds, which are poorly understood, but are key intermediates in many cobalt-catalyzed reactions. Through this project, Dr. Guan and his team will be actively engaged in outreach and training activities that benefit students from underrepresented groups, including those participating in the Undergraduates Pursuing Research in Science and Engineering Program at the University of Cincinnati and the ACS Project SEED Program as well as from collaborating predominantly undergraduate institutions. Dr. Guan will also develop research-based course materials and spectral resources that are expected to enhance the educational experience.In this project, Professor Hairong Guan and his research team aim to develop an understanding of how different ligand platforms impact the reactivity of cobalt hydrides. This research project will focus on elucidating the mechanistic details of hydrosilylation, hydroboration, and hydrophosphination reactions catalyzed by monophosphine-stabilized cobalt hydride complexes, and explore new reactions catalyzed by pincer-ligated cobalt hydrides. Also under investigation will be how pi-allyl and hydroxycyclopentadienyl cobalt complexes behave as masked hydrides in hydrogen transfer reactions as well as electrocatalysts for the reduction of carbon dioxide and the dehalogenation of chlorinated and fluorinated compounds. The proposed research studies are expected to contribute to the foundational knowledge of cobalt hydrides in catalysis. The lessons learned in these studies have the potential for broad scientific impact in the larger field of earth abundant transition metal catalysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学催化计划的支持下，辛辛那提大学的Haigong Guan教授及其小组将研究钴氢化钴的催化活性。催化在药物，能量和材料应用的化学合成中起着必不可少的作用。贵金属通常是设计催化剂的首选金属。但是，它们昂贵，供应量有限，有时难以从产品中删除。在这个项目中，关博博士将专注于一种廉价且丰富的金属钴，以研究带有钴氢键的分子的反应性，这些分子的理解很少，但在许多钴催化反应中都是关键的中间体。通过该项目，Guan博士和他的团队将积极从事宣传和培训活动，使辛辛那提大学的科学与工程计划研究的本科生和ACS Project Seed计划以及与合作的研究学院的研究学院，包括参加科学与工程研究计划的本科生，包括那些参加科学与工程学计划的本科生。 Guan博士还将开发基于研究的课程材料和光谱资源，这些资源有望增强教育经验。在该项目中，Hairong Guan教授及其研究团队旨在对不同的配体平台如何影响钴液体的反应性有所了解。该研究项目将着重于阐明由单膦稳定的钴氢化钴络合物催化的氢硅烷化，水力化和水磷酸反应的机理细节，并探索了由钳子粘合的钴氢酯催化的新反应。同样，正在研究的还将是Pi-Alyl和羟环戊二烯基钴复合物在氢转移反应中的掩盖液体以及用于还原二氧化碳和氯化和氟化化合物的脱核化的电催化剂中的表现。 拟议的研究预计将有助于催化中钴氢化钴的基础知识。这些研究中学到的经验教训具有在地球丰富的过渡金属催化领域中产生广泛的科学影响。该奖项反映了NSF的法定任务，并且使用基金会的智力优点和更广泛的影响评估标准，认为值得通过评估来获得支持。