I-Corps: Translation Potential of Simultaneous Musculoskeletal Assessment with Real-Time Ultrasound

I-Corps：实时超声同步肌肉骨骼评估的转化潜力

• 批准号: 2413735
• 负责人: Siddhartha Sikdar
• 金额: $ 5万
• 依托单位: George Mason University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2413735&HistoricalAwards=false
• 关键词: Corps; Translation; Potential; Simultaneous; Musculoskeletal

The broader impact of this I-Corps project is the development of a Simultaneous Musculoskeletal Assessment with Real-Time Ultrasound technology that enables muscle function monitoring during athletic training and rehabilitation post-musculoskeletal injuries. This innovation enables quantitative, metricized tracking of rehabilitation effectiveness, thereby enhancing the patient's recovery progress using non-invasive muscle-level imaging. Developments in such wearable ultrasound technologies can potentially transform athlete rehabilitation and military personnel training. By enabling real-time objective evaluations of muscle response to rehabilitation programs, the technology could shorten recovery periods in varied ways. For sports medicine staff, it could be used as a tool for fine-tuning return to play by monitoring rehabilitation post musculoskeletal injury in athletes. Similarly, military training centers could leverage this tool to measure new recruits' training and monitor a warfighter's muscle readiness pre- and post-mission, using specific fatigue biomarkers. This multifaceted approach to monitoring rehabilitation outcomes and operational readiness could be applied to medical rehabilitation, athlete performance optimization, and military training efficiency.This I-Corps project utilizes experiential learning coupled with a first-hand investigation of the industry ecosystem to assess the translation potential of the technology. The solution is based on the development of a Simultaneous Musculoskeletal Assessment with Real-Time Ultrasound system that enables detailed muscle-level assessments during rehabilitation exercises, without obstructing human movement. This system combines the utility of ultrasound imaging with the flexibility of small, multi-site, non-intrusive wearable sensors—a capability beyond the reach of conventional hand-held ultrasound systems. This system utilizes motion-mode imaging for subjects during dynamic tasks, unlocking opportunities to discover novel biomarkers and insights into musculoskeletal health and recovery processes in real-time. Ongoing research demonstrates that this innovation offers a reliable means to evaluate muscle function during rehabilitation activities, monitor the progression of muscle recovery over time, and deliver precise, real-time objective data on musculoskeletal health.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响是通过实时超声技术进行同时进行肌肉骨骼评估，从而在体育训练和康复后肌肉肌肉骨骼损伤期间实现肌肉功能监测。这项创新可实现康复效果的定量，度量标准的跟踪，从而使用非侵入性肌肉级成像来增强患者的恢复进度。这种可穿戴超声技术的发展可能会改变成人康复和军事人员培训。通过对肌肉对康复计划的反应进行实时客观评估，该技术可以以各种方式缩短恢复期。对于运动医学人员来说，它可以用作通过监测运动员肌肉骨骼损伤后的康复来进行微调重返游戏的工具。同样，军事训练中心可以利用特定的疲劳生物标志物利用该工具来测量新兵的训练，并在拆卸前后的肌肉准备就绪。这种监测康复结果和操作准备的多方面方法可用于医疗康复，运动员绩效优化和军事训练效率。这个I-Corps项目利用专家学习以及行业生态系统的第一手投资来评估技术的翻译潜力。该解决方案是基于与实时超声系统同时进行肌肉骨骼评估的开发，该系统可以在康复练习中详细的肌肉水平评估，而不会阻碍人类的运动。该系统将超声成像的实用性与小型多站点，非侵入性可穿戴传感器的灵活性（超出传统手持超声系统触手可及的功能）的灵活性相结合。该系统在动态任务中利用了动态模式成像，以实时发现新颖的生物标志物以及对肌肉骨骼健康和恢复过程的见解的机会。正在进行的研究表明，这项创新提供了一种可靠的手段，可以在康复活动期间评估肌肉功能，监控肌肉恢复的进展，并提供有关肌肉骨骼健康的精确，实时的实时客观目标数据。该奖项反映了NSF的法定任务，并通过使用该基金会的知识优点和广泛影响来通过评估来获得评估，以评估是有价值的。