I-Corps: Translation Potential of Simultaneous Musculoskeletal Assessment with Real-Time Ultrasound

I-Corps：实时超声同步肌肉骨骼评估的转化潜力

• 批准号: 2413735
• 负责人: Siddhartha Sikdar
• 金额: $ 5万
• 依托单位: George Mason University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2413735&HistoricalAwards=false
• 关键词: Corps; Translation; Potential; Simultaneous; Musculoskeletal

The broader impact of this I-Corps project is the development of a Simultaneous Musculoskeletal Assessment with Real-Time Ultrasound technology that enables muscle function monitoring during athletic training and rehabilitation post-musculoskeletal injuries. This innovation enables quantitative, metricized tracking of rehabilitation effectiveness, thereby enhancing the patient's recovery progress using non-invasive muscle-level imaging. Developments in such wearable ultrasound technologies can potentially transform athlete rehabilitation and military personnel training. By enabling real-time objective evaluations of muscle response to rehabilitation programs, the technology could shorten recovery periods in varied ways. For sports medicine staff, it could be used as a tool for fine-tuning return to play by monitoring rehabilitation post musculoskeletal injury in athletes. Similarly, military training centers could leverage this tool to measure new recruits' training and monitor a warfighter's muscle readiness pre- and post-mission, using specific fatigue biomarkers. This multifaceted approach to monitoring rehabilitation outcomes and operational readiness could be applied to medical rehabilitation, athlete performance optimization, and military training efficiency.This I-Corps project utilizes experiential learning coupled with a first-hand investigation of the industry ecosystem to assess the translation potential of the technology. The solution is based on the development of a Simultaneous Musculoskeletal Assessment with Real-Time Ultrasound system that enables detailed muscle-level assessments during rehabilitation exercises, without obstructing human movement. This system combines the utility of ultrasound imaging with the flexibility of small, multi-site, non-intrusive wearable sensors—a capability beyond the reach of conventional hand-held ultrasound systems. This system utilizes motion-mode imaging for subjects during dynamic tasks, unlocking opportunities to discover novel biomarkers and insights into musculoskeletal health and recovery processes in real-time. Ongoing research demonstrates that this innovation offers a reliable means to evaluate muscle function during rehabilitation activities, monitor the progression of muscle recovery over time, and deliver precise, real-time objective data on musculoskeletal health.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛影响是开发了一种实时超声同步肌肉骨骼评估技术，该技术可以在运动训练和肌肉骨骼损伤后康复期间进行肌肉功能监测。这一创新实现了对康复效果的定量化、度量化跟踪，从而使用非侵入性肌肉水平成像来增强患者的恢复进度。这种可穿戴超声技术的发展可能会改变运动员康复和军事人员培训。通过实时客观评估肌肉对康复计划的反应，该技术可以以各种方式缩短恢复期。对于运动医学工作人员来说，它可以作为一种工具，通过监测运动员肌肉骨骼损伤后的康复情况来微调重返赛场。同样，军事训练中心可以利用这种工具来测量新兵的训练，并使用特定的疲劳生物标志物来监测战士在任务前和任务后的肌肉准备情况。这种监测康复结果和运营准备的多方面方法可以应用于医疗康复，运动员性能优化和军事训练效率。该I-Corps项目利用体验式学习以及对行业生态系统的第一手调查来评估该技术的转化潜力。该解决方案基于实时超声同步肌肉骨骼评估系统的开发，该系统可在康复训练期间进行详细的肌肉水平评估，而不会阻碍人体运动。该系统将超声成像的实用性与小型、多部位、非侵入式可穿戴传感器的灵活性相结合，这是传统手持式超声系统无法实现的功能。该系统在动态任务期间利用受试者的运动模式成像，从而有机会发现新的生物标志物，并实时了解肌肉骨骼健康和恢复过程。正在进行的研究表明，这一创新提供了一种可靠的方法来评估康复活动中的肌肉功能，监测肌肉恢复随时间的进展，并提供精确，实时的客观数据对肌肉骨骼健康。该奖项反映了NSF的法定使命，并已被认为是值得支持的评估使用基金会的智力价值和更广泛的影响审查标准。