Collaborative Research: Chemo-Physics and Molecular Design of In-situ Hydrogel-MXene Biosensors
合作研究:原位水凝胶-MXene生物传感器的化学物理和分子设计
基本信息
- 批准号:2414719
- 负责人:
- 金额:$ 25.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-12-15 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Colorectal cancer (CRC) has a significant global impact, affecting 2 million people worldwide and standing as the third leading cause of cancer-related deaths in the United States. Technologies that enable in-situ monitoring of biomarkers closely related to the development and progression of CRC are highly desirable for timely diagnosis, early intervention, and personalized treatment of CRC. However, the complicated chemical, biological, and mechanical factors within complex physiological environments present substantial challenges in achieving specific, sensitive, and durable early detection of CRC. With support from the Biosensing Program in the Division of Chemical, Bioengineering, Environmental and Transport Systems and the Chemical Measurement and Imaging Program in the Division of Chemistry, the research groups of Prof. Shaoting Lin (Michigan State University), Prof. Chenglin Wu (Missouri University of Science and Technology), and Prof. Xinyue Liu (Michigan State University) aim to overcome these challenges by developing in-situ hydrogel-MXene biosensors capable of detecting low-level CRC biomarkers (e.g., carcinoembryonic antigen (CEA)) in simulated intestinal environments. The in-situ hydrogel-MXene biosensor will potentially lead to a big leap in bioelectronics, offering transformative impacts in disease diagnostics and paving the way for personalized healthcare. In addition, this project is expected to foster the development of the next-generation workforce in emerging biotechnologies through multi-institutional and interdisciplinary efforts including the integration of new topics in undergraduate courses and the promotion of STEM fields to encourage more students to engage in these areas of study.The goal of this project is to integrate selective-permeable hydrogels with MXene-based field-effect transistors for developing high-performance hydrogel-MXene biosensors that can achieve in-situ detection of low-level colorectal cancer (CRC) biomarkers (e.g., carcinoembryonic antigen (CEA)) in simulated intestinal environments while mitigating the influence of mobile ions. To achieve this, this project will leverage molecular design of reversible interaction, network topology, and fixed charge in hydrogels to modulate hydrogel-intestine interactions for selective biomolecular transport and to regulate hydrogel-MXene interactions for improved field-effect sensing performance. Specifically, this project will leverage the synergy of network elasticity and reversible interaction in hydrogels to independently modulate the transport of target and non-target biomolecules, thereby enabling selective and enhanced transport. In addition, this project will harness the combined efforts of molecular design, atomic simulation, and DFT calculation to optimize the design of network topology and fixed charge density of hydrogels, thus maximizing the Debye length, reduce the capacitance, and tune the bandgap at the hydrogel-MXene interface. Finally, this project will incorporate the explored hydrogel design principles to build a high-performing hydrogel-MXene biosensor capable of quantifying CRC biomarkers in simulated intestinal environments.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
结直肠癌(CRC)具有重大的全球影响,影响全球200万人,并成为美国癌症相关死亡的第三大原因。能够原位监测与CRC的发展和进展密切相关的生物标志物的技术对于CRC的及时诊断、早期干预和个性化治疗是非常理想的。然而,复杂的生理环境中复杂的化学、生物和机械因素对实现CRC的特异性、灵敏性和持久性早期检测提出了实质性挑战。在化学、生物工程、环境与运输系统系生物传感项目和化学系化学测量与成像项目的支持下,(密歇根州立大学),吴成林教授(密苏里州科技大学),和Xinyue Liu教授(密歇根州立大学)旨在通过开发能够检测低水平CRC生物标志物(例如,癌胚抗原(CEA))。原位水凝胶-MXene生物传感器将可能导致生物电子学的巨大飞跃,为疾病诊断提供变革性影响,并为个性化医疗保健铺平道路。此外,本发明还提供了一种方法,该项目旨在通过多机构和跨学科的努力,包括在本科课程中整合新课题,以及促进STEM领域,以鼓励更多学生从事这些领域的研究,促进新兴生物技术的下一代劳动力的发展。该项目的目标是将选择性渗透水凝胶与MXene基领域相结合,用于开发高性能水凝胶-MXene生物传感器的效应晶体管,所述水凝胶-MXene生物传感器可以实现低水平结肠直肠癌(CRC)生物标志物(例如,癌胚抗原(CEA)),同时减轻移动的离子的影响。为了实现这一目标,该项目将利用水凝胶中可逆相互作用,网络拓扑结构和固定电荷的分子设计来调节水凝胶-肠道相互作用以进行选择性生物分子运输,并调节水凝胶-MXene相互作用以改善场效应传感性能。具体而言,该项目将利用水凝胶中网络弹性和可逆相互作用的协同作用,独立调节靶和非靶生物分子的运输,从而实现选择性和增强的运输。此外,该项目将利用分子设计,原子模拟和DFT计算的综合努力来优化水凝胶的网络拓扑结构和固定电荷密度的设计,从而最大化德拜长度,降低电容,并调整水凝胶-MXene界面的带隙。最后,该项目将结合探索的水凝胶设计原则,构建一种高性能的水凝胶-MXene生物传感器,能够在模拟肠道环境中量化CRC生物标志物。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Chenglin Wu其他文献
Steroid-resistant acute rejection after cadaveric liver transplantation: experience from one single center.
尸体肝移植后类固醇耐药性急性排斥反应:来自单一中心的经验。
- DOI:
10.1016/j.clinre.2014.04.005 - 发表时间:
2014 - 期刊:
- 影响因子:2.7
- 作者:
Lin;N. Tam;R. Deng;Chenglin Wu;Philip Chen;Dong;Xiaoshun He - 通讯作者:
Xiaoshun He
An Unexpected Partnership: MHC Class II Molecules as Ligands for NK Cells.
意想不到的合作:MHC II 类分子作为 NK 细胞的配体。
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:6.2
- 作者:
Chenglin Wu;X. Li - 通讯作者:
X. Li
Association between overt aggression and suicidal ideation in patients with major depressive disorder: the mediational role of cognitive symptoms
- DOI:
10.1007/s00406-025-01979-0 - 发表时间:
2025-03-04 - 期刊:
- 影响因子:3.700
- 作者:
Ningning Chen;Meiti Wang;Yiming Chen;Fan Wang;Qinte Huang;Dongbin Lyu;Chenglin Wu;Vivien Yang;Shuang He;Xirui Liu;Yixia Xie;Qinting Zhang;Wu Hong - 通讯作者:
Wu Hong
h1 style=font-size:1.231em;font-family:arial, helvetica, clean, sans-serif;background-color:#FFFFFF; Simultaneous pancreas and kidney transplantation for liver transplant recipients with diabetes and uremia /h1 br /
糖尿病合并尿毒症肝移植受者同步胰肾移植
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:2.7
- 作者:
Jianwei Lin;Chenglin Wu;Ronghai Deng;Bing Liao;Shuiqing Hu;Dongping Wang;Xiaofeng Zhu;Linwei Wu;Xiaoshun He - 通讯作者:
Xiaoshun He
Mortality and Morbidity in Adults With Rheumatic Heart Disease.
成人风湿性心脏病的死亡率和发病率。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Ganesan Karthikeyan;M. Ntsekhe;S. Islam;S. Rangarajan;Á. Avezum;Alexander Benz;T. T. Cabral;Changsheng Ma;Philly Chillo;J. A. González;B. Gitura;Albertino Damasceno;A. Dans;K. Davletov;A. Elghamrawy;A. Elsayed;G. Fana;Lillian Gondwe;Abraham Haileamlak;A. Kayani;P. Lwabi;F. Maklady;O. J. Molefe;J. Musuku;O. Ogah;Maria Paniagua;Emmanuel Rusingiza;S. K. Sharma;L. Zuhlke;Stuart Connolly;Salim Yusuf;M. Goepamang;Julius Mwita;Auristela Ramos;Flávio Tarasoutchi;M. Paixão;Marcelo Kirschbaum;Mariana Pezzute Lopes;Walkiria Avila;Lilia Maia;Marcelo Nakazone;Osana Costa;Maria Lemos;Livia Oliveira;Jose Ferreira;J. F. Saraiva;Midia Costa;Marina Marengo;O. Dutra;Raphael Guimaraes;Humberto Vaz;Sergio Luiz Zimmerman;Weimar Souza;Weimar Queiroz;Adriana Souza;M. Vidotti;Jose Guilherme de Paula;G. Fazolli;Mauro Hernandes;José Luiz Simon Torati;Grazielly Pantano;Vanessa Pelarin;Flavia Arantes;Rodrigo Silva;Monique Cardoso;Gilmar Reis;César França;Tulio Quadros;F. Giorgeto;Resende Elmiro;Silva Aguinaldo;Cesar Minelli;Helen Mbuoh Anshoma;J. Ambassa;Liliane Mfevkev Kuate;Chris Nadege Nganou Gninotio;Ngo Youmba Ntep Gweth;Dzudie Anastase;Djomou Ngongang Florent Armel;Lionel Nana Keptukoua;Xin Du;Rong Hu;Jiahui Wu;Qiang Lv;Jing Cui;Yu Qing;Xudong Zhu;Wei Su;Xiaomei Wang;Chen Shiyi;Zhipeng Zhang;Qi Wang;Xin Zheng;Pengfei Liu;Cheng Rang;Sitao Xie;Chongwen Liu;Hailong Wang;Shudong Wang;Xuxia Zhang;Yinzhu Lian;Rui Wang;Mingfu Ma;Lan Dou Li;Yunlian Tan;Shouyan Zhang;Yunfei Gu;Jianfeng Chen;Wang Hao;Pengyu Wu;Luan Hong;Li Fu;Yongbin Xu;Jundan Xiao;Qingfu Li;Jinpo Sun;Cui Pei;Yanbo Niu;Yidi Wu;Honghua Yang;Xin Li;Chunyan Yang;Yanhui Shi;Chenglin Wu;Yandong Qu;Mingzhong Zhao;Yong Cheng;Yiqiang Yuan;Qiong Huang;Xiuzhen Kong;Zhizhong Zhao;Qixia Heng;Xinjing Shi;Jing Zhang;Liu Ying;Gao Xin;Zhaoping Yu;Xi Wu;Guo Hunayu;Xiaoying Wang;Wei Zhang;Chichang Li;Zhongtao Wang;Hao Ding;Min Huang;Jinguo Zhao;Mingshui Yu;Cuiling Cao;Xiaoli Zhu;Xiaoqin Shi;Khalid Eltamawy;Osama Arafa;Mahmoud Youssif;Aly Kassem;Omar Saleh;Mohamed Hussam Al Shair;Khaled Maghraby;Sameh Shaheen;Aly Ahmed Abouelhoda;Suliman Gharib;Ramadan Sadek;Yasser Abd El Hady;E. Asefa;E. K. Gudina;Ermias Habte Michael;Tadesse Dukessa Gemechu;Markos Duguma;Dejuma Yadeta;Berhanu N Alemu;Sintayehu Abebe;Tamrat Assefa;D. Mekonnen;Tigist Seleshi;Chala Fekadu;Abraha Hailu;Hagazi Tesfay;Berhane Yohannes Hailu;Hagos Kahsay;Kibreab Gidey;Teklay Gebrehawaria;Samuel Berhane;Teshome Abegaz Kamil;Tariku Egeno Shifa;Agete Tedewos Hirigo;Sisay Tesfaye Teshome;Seyife Kibru Yirdaw;Sandeep Singh;Nitish Naik;Deepti Siddharthan;Satyavir Yadav;Mohit Gupta;Girish Mp;Ajay Sharma;B. Pandit;Kumar Sudeep;Kapoor Aditya;A. Pradhan;R. Sethi;Gaurav Chaudhry;Yaday Virendra;Agarwal Smriti;Cholenahally Manjnath;Surya Prakash Narayanappa;Cholenahally Satvic;Lachikarthman Devegowda;C. Meena;Rajiv Bagarhatta;Shashi Mohan Sharma;S. Kunal;Nutan Kumar;A. Mereke;Elijah Ogola;Wilson Sugut;F. Barasa;Anthony Gikonyo;Stephen Omondi;Frank Sinyiza;John Chipolombwe;Tamara Phiri;Laura Leticia Rodriguez Chavez;Ernesto Gutierrez;Fransisco Mazon Flores;Edgar Rodriguez;Susano Lara Vaca;Juan Cabra;Sandra Saavedra;Manuel De los Rios;Gilmer Ruvalcaba;Esteban Lopez;Marco Alcocer;Ana Ramirez;Guillermo Llamas;Paola Hernandez;Angelica Delgado;Ana Muholove;Angela Mateus;A O Mocumbi;Jyoti Agarwal;Roshan Chhetri;Prashant Mani Tripathi;C. Adhikari;Urmila Shakya;D. Prajapati;R. Manandhar;Rajesh Nepal;S. Dhungana;R. Ghimire;S. Khanal;Samir Gautam;Mazhar Khan;B. Kc;S. Laudari;Madhu Gupta;S. Regmi;B. Dhital;Sudhir Regmi;K. Adhikari;Bhagawan Koirala;R. Gajurel;H. Shrestha;S. Thapa;A. Akintunde;T. Olunuga;Julius Adesina;Mahmoud Sani;F. Bode‐Thomas;Basil Okeahialam;C. Yilgwan;G. Amusa;O. Ige;Solomon Danbauchi;A. Adeoye;Ejiroghene Umuerri;A. Mbakwem;C. Amadi;Oyewole A Kushimo;Muhammad Isa;Muhammad Awwal Abdullahi;Nelson Oguanobi;Zohaib Ullah Zahid;Jabar Ali;M. Hafizullah;F. Memon;Shazia Kazi;A. Kayani;Adeel Rehman;Abdul Wajid Khan Faisal;Aftab Ahmad Tarique;Abdul Sattar;Nadeem Hayat Mallick;Syed Asif Ali;Veronica Mayans;Luciano Pereira;Jose Alderete;Javier Galeano;Alberto Moran Salinas;Rocío del Pilar Falcón;Gustavo Escalada;Luz Cabral;Liz Fatecha;Gladys Bogado de Atobe;Carlos Gutierrez;César Delmás;Claudine Coronel;Dahiana Ibarrola;Jose Donato Magno;Lauren Kay Evangelista;M. T. Abola;Leahdette Padua;Christie Mendoza;D. Sulit;Ma Jojo Mercado;Candy Angelica Sigua Cabaddu;Josefina Cruz;Jean Marie Vianney Ganza Gapira;Vincent Dusingizimana;B. Cupido;John Lawrenson;Kishendree Naicker;Jacqueline Rachelle Cirota;Sliwa Hahnle Karen;Mookenthottathil Thomas Baby;Kandathil M Thomas;Moeketsi Khulile;S. Alomatu;P. Mntla;Makgotsane Mphahlele;Andrew Ratsela;Pravin Manga;Doné Fourie;A. Hemus;E. M. Makotoko;A. K. M. N. Alam;R. Nethononda;Theema Nunkoo;Ruchika Meel;Elsadig Askar;A. Elfaki;Lana Mohamed;Mohammed ElSayed;Alia Hagahmed;Sumia Mohammed;Hiba Algaali;K. Eltalib;Tagwa S. I. Badawe;Inas Hassab Elrasoul Kbashi;H. Elhassan;M. Hamza;Molhim M.I. Ahmed;Rayan Elhussain;Rufaida Mutwali;Mohammad Qurashi Ahmed Medani;Nazar F.A. Mohamed;Hwida A.M. Elamin;Manal H.A. Elmadih;Maha Abdelgader;Magdi G. Yousif;Tagwa Elfatih;O. Elshazali;Elaf Esmaeel Esawi;Awad A.M.A. Mohammed;Omer I.A. Hassan;Khansa Mahgoub;Maarib Maki;Omaima A.M.Abozaid;Naiz Majani;Emmanuel Stephano Mtullo;Clement Kabakama;I. Mwakyula;J. Meda;E. Okello;P. Chansa;Ngosa Mumba;Fastone Goma;Caroline Musemwa;Rudo Gwini - 通讯作者:
Rudo Gwini
Chenglin Wu的其他文献
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{{ truncateString('Chenglin Wu', 18)}}的其他基金
Collaborative Research: Chemo-Physics and Molecular Design of In-situ Hydrogel-MXene Biosensors
合作研究:原位水凝胶-MXene生物传感器的化学物理和分子设计
- 批准号:
2320717 - 财政年份:2023
- 资助金额:
$ 25.81万 - 项目类别:
Standard Grant
Atomic-Layer Dependent Adhesion of Two-Dimensional Transitional Metal Carbides (MXenes)
二维过渡金属碳化物 (MXenes) 的原子层依赖性粘附
- 批准号:
2414708 - 财政年份:2023
- 资助金额:
$ 25.81万 - 项目类别:
Standard Grant
CAREER: Chemomechanics of 2D Transition Metal Materials
职业:二维过渡金属材料的化学力学
- 批准号:
2414716 - 财政年份:2023
- 资助金额:
$ 25.81万 - 项目类别:
Standard Grant
Collaborative Research: NRI: Smart Skins for Robotic Prosthetic Hand
合作研究:NRI:机器人假手智能皮肤
- 批准号:
2221190 - 财政年份:2022
- 资助金额:
$ 25.81万 - 项目类别:
Standard Grant
CAREER: Chemomechanics of 2D Transition Metal Materials
职业:二维过渡金属材料的化学力学
- 批准号:
2045070 - 财政年份:2021
- 资助金额:
$ 25.81万 - 项目类别:
Standard Grant
Atomic-Layer Dependent Adhesion of Two-Dimensional Transitional Metal Carbides (MXenes)
二维过渡金属碳化物 (MXenes) 的原子层依赖性粘附
- 批准号:
1930881 - 财政年份:2019
- 资助金额:
$ 25.81万 - 项目类别:
Standard Grant
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