Immobilization of Hydrogen-Bonded Capsules on Silicon Wafer

在这个项目中，我们的目标是将氢键胶囊固定在硅片上，并探索这些分子结构的物理有机和材料性质，目的是开发药物传递系统和超分子维可牢。我们将合成具有烯烃脚的空腔体，这些空腔体可以自组装成由各种客体分子模板化的胶囊结构。末端烯烃非常适合通过硅氢化作用在端氢硅上光化学或热沉积空腔体。为了表征和研究修饰的表面和胶囊自组装，我们将使用多种表面分析方法以及客体4,4-二甲基苄基的包封使能荧光开启特性。这里使用的胶囊结构由非常强的氢键连接在一起，甚至可以在水中生存。因此，该系统可能非常适合用于适合胶囊腔的适当形状的药物分子的药物输送系统。同时，超分子维可牢可以由表面间的胶囊自组装而成，该系统可以在真空、空气和各种溶剂中生存，因此具有广泛的应用前景。此外，胶囊的形成强烈依赖于客人的模板效应。因此，这种超分子尼龙搭扣的强度可以通过使用不同的客体分子来调节。例如，一种可光开关的客体，如4,4-二甲基偶苯，甚至可以赋予超分子尼龙搭扣光开关性。因此，我们相信本项目的研究将为超分子结构修饰表面的应用开辟新的领域。

In this project, we are aiming at the immobilization of hydrogen-bonded capsules on silicon wafers and explore the physical organic and material properties of these molecular architectures with purpose to develop drug-delivery systems and supramolecular Velcro. We will synthesize cavitands with alkene feets which can self-assemble into capsular structures templated by a variety of guest molecules. The terminal alkenes are well suited for a photochemical or thermal deposition of the cavitands on hydrogen-terminated silicon through hydrosilylation. For the characterization and study of the modified surface and capsule self-assembly we will use multiple surface analysis methods as well as the encapsulation-enabled fluorescence turn-on properties of guest 4,4-dimethylbenzil. The capsular structures used here are held together by very strong hydrogen bonds and can even survive in water. Therefore, this system may be well suited to a drug-delivery system for appropriate shaped drug molecules which fit into the capsule`s cavity. Meanwhile, a supramolecular Velcro can be constructed from an inter-surface capsule self-assembly and this system may survive in vacuum, air and a variety of solvents and thus finds broad applications. In addition, the capsule formation is strongly dependent on the template effect of guests. Therefore, the strength of this supramolecular Velcro may be well tuned by using different guest molecules. For example, a photo-switchable guest, such as 4,4-dimethylazobenzene, may even endow the supramolecular Velcro with photoswitchability. Therefore, we believe the research in this project will open new frontiers for applications of surfaces modified by supramolecular architectures.