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Emotion regulation in Borderline Personality Disorder: functional neuronal correlates of habitual and instructed acceptance and suppression of positive and negative emotions

边缘性人格障碍的情绪调节：习惯性和指导性接受和抑制积极和消极情绪的功能神经相关性

基本信息

批准号：
260615460
负责人：
Professor Dr. Thomas Beblo, since 9/2014
金额：
--
依托单位：
Klinik für Psychiatrie und Psychotherapie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2014
资助国家：
德国
起止时间：
2013-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/260615460?language=en
关键词：
Emotion regulation Borderline Personality Disorder

项目摘要

Patients with borderline personality disorder (BPD) are characterized by affective instability which comprises the experience of rapidly changing, intensive emotional states. It has been argued that affective instability is reinforced and preserved by the use of maladaptive emotion regulation strategies, i. e. suppression of emotions. Behavioral research indicates that emotional suppression consecutively leads to a rebound-effect which includes a paradoxical increase of emotional arousal. It seems likely that the same applies for patients with BPD. In contrast, it is assumed, e.g. in Dialectical Behavior Therapy of BPD, that acceptance of emotions has positive effects on emotional well-being. However, research is missing on the short- and long-term effects of suppression and acceptance of emotions on a neuronal level in patients with BPD. With functional magnetic resonance tomography (fMRT) we address the question of whether emotional suppression contributes to enhanced affect intensity in BPS. On the one hand, we correlate the habitual use of emotional suppression and acceptance as assessed with questionnaires with the neuronal activity in reaction to emotional (negative and positive) visual stimuli. On the other hand, we examine the effects of instructed use of suppression and acceptance of emotions in reaction to emotional visual stimuli after completion of a short emotion regulation training. We expect that emotional suppression in contrast to acceptance causes a rebound-effect of emotional arousal in (para-) limbic brain regions, which is particularly pronounced in patients with BPD compared to a depressive and a healthy control group. Our research findings also provide important implications for the therapy of BPS.

边缘型人格障碍(BPD)患者的特点是情绪不稳定，包括快速变化的、强烈的情绪状态的经历。有人认为，情绪不稳定是通过使用非适应性情绪调节策略来加强和保持的，即抑制情绪。行为研究表明，情绪压抑会连续导致反弹效应，其中包括自相矛盾的情绪唤醒增加。这似乎也适用于BPD患者。相反，在BPD的辩证行为疗法中，人们假设接受情绪对情绪幸福感有积极影响。然而，缺乏关于抑制和接受情绪在神经元水平上对BPD患者的短期和长期影响的研究。通过功能磁共振断层扫描(FMRT)，我们解决了情绪压抑是否有助于BPS患者情感强度增强的问题。一方面，我们将问卷评估的情绪抑制和接受的习惯性使用与对情绪(消极和积极)视觉刺激的反应的神经元活动联系起来。另一方面，我们考察了在完成短期情绪调节训练后，对情绪视觉刺激的反应中，有指导地使用抑制和接受情绪的效果。我们预计，与接受相反的情绪压抑会在(边缘附近)大脑区域引起情绪唤醒的反弹效应，与抑郁和健康对照组相比，这种反弹效应在BPD患者中尤为明显。我们的研究结果也为BPS的治疗提供了重要的启示。