NHC-stabilized nickel complexes in the C-F- und C-H-bond activation of polyfluorinated aromatics

NHC 稳定的镍配合物在多氟芳烃 C-F 和 C-H 键活化中的作用

• 批准号: 261421779
• 负责人: Professor Dr. Udo Radius
• 金额: --
• 依托单位: Institut für Anorganische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/261421779?language=en
• 关键词: NHC; stabilized; nickel; complexes; und

The project aims at the development of stoichiometric and catalytic protocols for nickel-mediated manipulations of fluoroorganic compounds. Within this project nickel complexes, which are stabilized with one or two NHC (NHC = N-Heterocyclic Carbene) ligands will be systematically investigated with respect to an application of these complexes in C-F- and C-H bond activation reactions of fluoroaromatics, the reaction mechanisms involved in these transformations, the selectivity of the bond activation step for the reaction with partially fluorinated substrates and fluorinated substrates with hetero atom substituents, as well as application of these complexes in catalytic reactions. A long term goal of the research project lies in the development of chemo- and regioselective reactions for the transfer of polyfluorinated building blocks to organic molecules and in the development of selective functionalization reactions of polyfluorinated arenes.

该项目旨在为镍介导的氟代有机化合物操作开发化学计量和催化协议。在该项目中，镍络合物，用一种或两种NHC稳定（NHC = N-杂环卡宾）配体在含氟芳烃的C-F-和C-H键活化反应中的应用、这些转化的反应机理、键活化步骤对于与部分氟化的底物和具有杂原子取代基的氟化底物反应的选择性，以及这些配合物在催化反应中的应用。该研究项目的长期目标在于开发用于将多氟结构单元转移到有机分子的化学和区域选择性反应，以及开发多氟芳烃的选择性官能化反应。

项目成果

Cyclic (Alkyl)(Amino)Carbene Complexes of Rhodium and Nickel and Their Steric and Electronic Parameters.

• DOI: 10.1002/chem.201601406
• 发表时间: 2016-07
• 期刊: Chemistry
• 作者: Ursula S. D. Paul;C. Sieck;Martin Haehnel;Kai Hammond;T. Marder;U. Radius

Preparing (Multi)Fluoroarenes as Building Blocks for Synthesis: Nickel-Catalyzed Borylation of Polyfluoroarenes via C-F Bond Cleavage.

• DOI: 10.1021/jacs.6b02337
• 发表时间: 2016-04
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Jing-Feng Zhou;Maximilian W. Kuntze‐Fechner;R. Bertermann;Ursula S. D. Paul;Johannes H. J. Berthel;A. Friedri

NHC Nickel Catalyzed Hiyama- and Negishi-Type Cross-Coupling of Aryl Fluorides and Investigations on the Stability of Nickel(II) Fluoroaryl Alkyl Complexes

NHC 镍催化芳基氟化物的桧山型和根岸型交叉偶联及镍(II)氟芳基烷基配合物的稳定性研究

• DOI: 10.1002/ejic.201801477
• 发表时间: 2019
• 期刊: European Journal of Inorganic Chemistry
• 影响因子: 2.3
• 作者: M. W. Kuntze-Fechner;C. Kerpen;D. Schmidt;M. Häring;U. Radius
• 通讯作者: U. Radius

What Wanzlick Did Not Dare To Dream: Cyclic (Alkyl)(amino)carbenes (cAACs) as New Key Players in Transition‐Metal Chemistry

• DOI: 10.1002/ejic.201700397
• 发表时间: 2017-08
• 期刊: European Journal of Inorganic Chemistry
• 影响因子: 2.3
• 作者: Ursula S. D. Paul;U. Radius

NHC Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions of Aryl Boronate Esters with Perfluorobenzenes.

• DOI: 10.1021/acs.joc.6b01041
• 发表时间: 2016-06
• 期刊: The Journal of organic chemistry
• 作者: Jing-Feng Zhou;Johannes H. J. Berthel;Maximilian W. Kuntze‐Fechner;A. Friedrich;T. Marder;U. Radius