Antibacterial and low-abrasive coatings on sliding surfaces of orthopedic implants

目前，假体周围感染的数量稳步上升，这对现代患者护理构成了严峻的挑战，无论是在临床还是在社会经济方面。因此，本提案（知识转移项目）的目的是为机械高应力内生假体开发非常有效的滑动表面，同时表现出有效的抗感染特性。这种多功能表面的轮廓路线是DFG之前的一个项目的结果，我们已经探索了我们研究的技术和生物基础。据我们所知，我们的创新，多功能滑动表面在世界范围内从未实现过。为了实现我们的目标，我们需要进一步开发技术来有效地将多功能薄膜涂层转移到光滑的金属或陶瓷植入表面，并进一步提高我们基于离子束注入的UHMWPE向DLC的转化。由于在最初植入组织时的抗菌要求，我们依赖于先前医学上证明的植入材料涂层，然后我们提供生物优化的银浓度。为了确保将我们的研究成果及时转移到医疗应用中，所有与批准相关的细节，如生物力学磨损行为、潜在磨损颗粒的物理和细胞生物学特性等，都将与我们的工业合作伙伴Aesculap AG密切合作，详细调查并符合标准。为了研究多功能表面在准体内条件下的粘附行为，我们通过血管芯片工具扩展了我们的研究，在这种工具中，植入细胞的相互作用和粘附过程可以在均匀脉动流条件下进行研究。此外，我们计划研究在植入材料和磨损碎片存在下淋巴细胞与模型膜和淋巴内皮细胞的相互作用。要成功实现包含许多复杂技术和研究领域的提案，最重要的先决条件是将来自专业大学研究小组和国际知名的德国植入物制造商的每个参与合作伙伴的现有专业知识进行协同结合。在经济上可行的基础上，在有关大学和工业伙伴之间进行系统的知识转移，本建议将为成功的医学技术开发和应用带来新的和长期的激励。因此，它也旨在可持续地保护甚至创造该行业的就业机会。该项目的目标是开发高效抗感染的内假体滑动表面。这是最大的临床和卫生保健的重要性，并开辟了新的创新选择，预防和治疗稳步增加的假体周围感染的数量。

The steadily rising number of periprothetic infections nowadays represents a serious challenge for modern patient care, in both clinical as well as socio-economical terms. It is thus the aim of the present proposal (knowledge transfer project) to develop very efficient sliding surfaces for mechanically highly stressed endoprotheses, which at the same time exhibit efficient anti-infectious properties. The outlined route towards such multifunctional surfaces is the result of a previous DFG project, where the technical and biological grounds of our research had been explored. To our knowledge, our innovative, multi-functional sliding surfaces have worldwide never been realized before. To achieve our goals, we need to further develop the technologies to effectively transfer the multi-functional thin film coatings to smooth metal or ceramic implant surfaces and to further improve our ion beam implantation based transformation of UHMWPE into DLC.Due to the antibacterial requirements during the initial implantation into the tissue, we rely on the coating of previously medically proven implant materials, which we then supply with biologically optimized silver concentrations. To ensure the timely transfer of our findings into medical applications, all approval-relevant details like biomechanical abrasion behavior, physical and cell biological properties of the potential wear particles etc. will be investigated in close cooperation in detail and conforming to standards with our industrial partner, the Aesculap AG.To investigate the adhesion behavior of the multi-functional surfaces under quasi in vivo conditions, we expand our investigations by a vessel-on-a-chip tool where the implant cell interaction and adhesion processes can be studied under even pulsatile flow conditions. Also, we plan to investigate the interaction of lymphocytes with model membranes and lymphatic endothelial cells in the presence of implant material and wear debris. The most important prerequisite for a successful realization of the proposal comprising many complex technological and research areas is the synergetic combination of the existing expertise profiles of each of the participating cooperation partners from specialized university research groups and an internationally renowned German implant manufacturer.On the basis of an economically feasible, systematic knowledge transfer between the involved universities and the industry partner, the present proposal will trigger new and long term incentives for a successful medico-technical exploitation and applications. It thus is also aiming towards the sustainable preservation or even creation of jobs in this industry. The goal of the proposed project is to pioneer with highly efficient anti-infective sliding surfaces for endoprotheses. It is of utmost clinical and health care importance and opens up new innovative options for the prevention and therapy of the steadily increasing number of periprosthetic infections.