Interaction of adhesion GPCR signalling and ionotropic pathways during mechano-sensory signal transduction

基于我们在果蝇体内观察到的黏附G蛋白偶联受体dCIRL作为代谢型机械感受器的作用，本项目将对dCIRL与TRP(瞬时受体电位)家族的亲电离机械转导通道之间的功能相互作用进行详细的研究。为了判断这种相互作用的普遍性，我们将重点研究两个机械感觉系统：(I)幼虫脊索器，用于检测外部机械刺激；(Ii)成年果蝇的特殊中枢神经元，用于监测内渗透压。

Building upon our observation that the adhesion G protein-coupledreceptor (aGPCR) dCIRL acts as a metabotropic mechanosensor inDrosophila, this project will carry out a detailed investigation of thefunctional interaction between dCIRL and ionotropicmechanotransduction channels of the TRP (transient receptorpotential) family. In order to judge the generality of such an interplay,we will focus on two mechanosensory systems: (i) the larvalchordotonal organ, which detects external mechanical stimuli and (ii)specialized central neurons of adult Drosophila, which monitor internalosmolality.