Interaction of adhesion GPCR signalling and ionotropic pathways during mechano-sensory signal transduction

机械感觉信号转导过程中粘附 GPCR 信号传导和离子传递途径的相互作用

• 批准号: 265996823
• 负责人: Professor Dr. Robert J. Kittel
• 金额: --
• 依托单位: Rudolf-Schönheimer-Institut für Biochemie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/265996823?language=en
• 关键词: Interaction; adhesion; GPCR; signalling; ionotropic

Building upon our observation that the adhesion G protein-coupledreceptor (aGPCR) dCIRL acts as a metabotropic mechanosensor inDrosophila, this project will carry out a detailed investigation of thefunctional interaction between dCIRL and ionotropicmechanotransduction channels of the TRP (transient receptorpotential) family. In order to judge the generality of such an interplay,we will focus on two mechanosensory systems: (i) the larvalchordotonal organ, which detects external mechanical stimuli and (ii)specialized central neurons of adult Drosophila, which monitor internalosmolality.

基于我们在果蝇中观察到的粘附G蛋白偶联受体（aGPCR）dCIRL作为一种代谢型机械力传感器，本项目将对dCIRL与瞬时受体电位（TRP）家族的离子型机械力转导通道之间的功能相互作用进行详细的研究。为了判断这种相互作用的一般性，我们将集中在两个mechanosensory系统：（i）larvalchordotonic器官，检测外部机械刺激和（ii）专门的中枢神经元的成年果蝇，监测internalosmolality。