Local and long-range tactile signal integration in defined cell types of primary somatosensory (barrel) cortex (C07)

C07将研究桶皮质中触觉信号整合中局部（桶皮质内）和远程（皮质下或来自其他皮质区域）回路的相互作用。我们将使用单突触逆行狂犬病追踪构建一个全脑范围的篮子，Martinotti和假定的神经元特异性双极细胞的局部和远程输入图谱，使用光遗传学来研究Martinotti和双极细胞如何整合局部与远程输入，并进行体内记录以表征单个主须和相邻须以及多须刺激的信号整合。通过这种多层次的方法，我们将阐明特定类型的GABA能神经元的解剖和功能连接体。

C07 will study the interaction of local (within the barrel cortex) and long-range (subcortical or from other cortical areas) circuits in tactile signal integration in the barrel cortex. We will construct a brain-wide atlas of local and long-range inputs to basket, Martinotti, and putative interneuron-specific bipolar cells using monosynaptic retrograde rabies tracing, use optogenetics to examine how Martinotti and bipolar cells integrate local with long-range inputs, and perform in vivo recordings to characterize signal integration of single principal and adjacent whisker as well as multiwhisker stimuli. With this multi-level approach we will clarify the anatomical and functional connectome of defined types of GABAergic neurons.