Local and long-range tactile signal integration in defined cell types of primary somatosensory (barrel) cortex (C07)

初级体感（桶状）皮质的特定细胞类型中的局部和远程触觉信号整合（C07）

• 批准号: 269028443
• 金额: --
• 依托单位: Institut für Neuroanatomie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/269028443?language=en
• 关键词: Local; long; range; tactile; signal

C07 will study the interaction of local (within the barrel cortex) and long-range (subcortical or from other cortical areas) circuits in tactile signal integration in the barrel cortex. We will construct a brain-wide atlas of local and long-range inputs to basket, Martinotti, and putative interneuron-specific bipolar cells using monosynaptic retrograde rabies tracing, use optogenetics to examine how Martinotti and bipolar cells integrate local with long-range inputs, and perform in vivo recordings to characterize signal integration of single principal and adjacent whisker as well as multiwhisker stimuli. With this multi-level approach we will clarify the anatomical and functional connectome of defined types of GABAergic neurons.

C07将研究局部(在桶状皮质内)和远程(皮质下或来自其他皮质区域)回路在桶状皮质中触觉信号整合中的相互作用。我们将使用单突触逆行狂犬病追踪技术，构建对Basket、Martinotti和假定的神经元间特异性双极细胞的局部和远程输入的全脑图谱，使用光遗传学来研究Martinotti和双极细胞如何将局部和远程输入整合在一起，并进行活体录音，以表征单个主要和邻近胡须以及多个胡须刺激的信号整合。通过这种多层次的方法，我们将阐明已定义类型的GABA能神经元的解剖学和功能连接体。