Evaluation of ATF3 in systemic sclerosis and fibrotic diseases

ATF3 在系统性硬化症和纤维化疾病中的评价

• 批准号: 269395205
• 负责人: Privatdozent Dr. Andreas Ramming
• 金额: --
• 依托单位: Medizinische Klinik 3 - Rheumatologie und Immunologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/269395205?language=en
• 关键词: Evaluation; ATF3; systemic; sclerosis; fibrotic

The hallmark of systemic sclerosis (SSc) is progressive fibrosis of the skin and internal organs accompanied by the abnormal activation of the immune system, vasculopathy, and a high risk of mortality. Despite the great medical need, anti-fibrotic therapies are not yet available for clinical use. The chronic activity of transforming growth factor (TGF)-b resulting in activation of fibroblasts and excessive accumulation of extracellular matrix is characteristic for SSc and other fibrotic diseases. The molecular mechanisms behind are still unknown. Activating transcription factor (ATF)3 might be an important factor in the pro-fibrotic signaling of TGF-b, since ATF3 is activated by TGF-b and involved in inflammation, tissue repair and vascular homeostasis. However, its function and regulation in fibrotic disorders are not understood yet. This project aims to investigate the role of ATF3 in the pathogenesis of fibrotic diseases.

系统性硬化症（SSc）的标志是皮肤和内脏器官的进行性纤维化，伴随着免疫系统的异常激活、血管病变和高死亡率。尽管有巨大的医疗需求，抗纤维化疗法尚未可用于临床。转化生长因子(TGF)-b的慢性活性导致成纤维细胞的激活和细胞外基质的过度积累是SSc和其他纤维化疾病的特征。其背后的分子机制尚不清楚。激活转录因子（ATF3）可能是TGF-b促纤维化信号的重要因子，因为ATF3被TGF-b激活，参与炎症、组织修复和血管稳态。然而，其在纤维化疾病中的功能和调控尚不清楚。本项目旨在探讨ATF3在纤维化疾病发病机制中的作用。

项目成果

Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis

• DOI: 10.1002/art.41058
• 发表时间: 2020-01-01
• 期刊: ARTHRITIS & RHEUMATOLOGY
• 影响因子: 13.3
• 作者: Soare, Alina;Gyoerfi, Hermina A.;Distler, Joerg H. W.
• 通讯作者: Distler, Joerg H. W.

Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis

• DOI: 10.1136/annrheumdis-2014-206214
• 发表时间: 2016-03-01
• 期刊: ANNALS OF THE RHEUMATIC DISEASES
• 影响因子: 27.4
• 作者: Mallano, Tatjana;Palumbo-Zerr, Katrin;Distler, Joerg H. W.
• 通讯作者: Distler, Joerg H. W.