Decarboxylative Arylations in Natural Product Synthesis and Transfer Hydrofunctionalizations Using Cyclohexadienes

在第二个项目期间，在第一个资助期间开发的pd催化脱羧γ -芳基化和其他方法将应用于合成各种芳基四聚木脂烷。在天然产物合成的同时，项目的一部分致力于方法开发。沿着这些路线，计划使用功能化的环己二烯衍生物作为Pd和ni催化烯烃转移加氢功能化的试剂。除了环己二烯衍生物外，n-磺酰基二氢吡啶也将作为过渡金属催化烯烃功能化的转移氢功能化试剂进行制备和研究。金属和配体的性质应该允许控制这种转化的区域化学和立体选择性。此外，同样的亲芳试剂也将应用于自由基型转移加氢功能化反应。

In the second project period, the Pd-catalyzed decarboxylative gamma-arylation and other methods developed during the first funding period will be applied to the synthesis of various aryltetralinlignanes. Along with natural product synthesis, one part of project is devoted to methods development. Along those lines, it is planned to use functionalized cyclohexadiene derivatives as reagents in Pd- and Ni-catalyzed alkene transfer hydrofunctionalizations. Besides cyclohexadiene derivatives, N-sulfonylated dihydropyridines will be prepared and studied as transfer hydrofunctionalization reagents in transition-metal catalyzed alkene functionalizations. The nature of the metal and the ligand should allow controlling regiochemistry as well as stereoselectivity of such transformations. In addition, the same proaromatic reagents will also be applied to radical-type transfer hydrofunctionalization reactions.