Metal-free Arylations for Green Chemistry

有机化学主要研究分子的合成。为了有效地合成，我们必须对原子之间的键可以形成或断裂的方式以及分子如何相互反应有合理的见解。在这个提议中，我们利用了一类有趣的含有碘原子的分子的特殊性质。我们建议合成新的试剂，并仅在催化量下使用这些试剂来研究反应。这意味着一个催化剂分子将有可能创造数千个具有特殊性质的新分子。这些新的碘试剂的发展和它们在允许芳香族部分选择性转移的各种反应中的应用构成了这一提议的主要部分。在这些反应中得到的目标结构存在于天然产物和许多药物中。因此，快速、无金属地获得此类化合物将使它们能够快速合成并促进新生物活性分子的开发。

Organic Chemistry is mainly dealing with the synthesis of molecules. For efficient synthesis, we must have reasonable insight into the way in which bonds between atoms can be formed or broken and how molecules can react with each other. In this proposal we make use of the special properties of an interesting class of molecules containing iodine atoms. We propose to synthesise novel reagents and investigate reactions using these reagents in only catalytic amounts. This means that one catalyst molecule will have the potential to create thousands of new molecules with special properties. The development of these new iodine reagents and their application in various reactions allowing the selective transfer of aromatic moieties form the main part of this proposal. The target structures which are obtained in these reactions are found in natural products and in many pharmaceuticals. A fast and metal-free access to such compounds will therefore enable their fast synthetic access and enhance the development of new bioactive molecules.