Novel Transformations Mediated by the Persistent NO Radical

由持久性 NO 自由基介导的新转变

• 批准号: 506303218
• 负责人: Professor Dr. Armido Studer
• 金额: --
• 依托单位: Organisch-Chemisches Institut
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/506303218?language=en
• 关键词: Novel; Transformations; Mediated; Persistent; NO

Nitroso compounds will be used as versatile radical precursors in various visible light mediated cascade reactions. A major focus will lie on the photochemical generation of C-radicals from alkyl nitroso compounds and their application in oxidative intermolecular addition reactions. These cascades are steered by the Persistent Radical Effect and the persistent NO radical mediates the transformations. Nucleophilic, amphiphilic as well as electrophilic C-radicals will be investigated applying this novel strategy. These photo-mediated reactions show high atom economy. Along with the photo-mediated radical generation, thermal variants will also be investigated and kinetics addressed. Photochemical Sigma-bond homolysis in nitroso derivatives will also be applied to the generation of heteroatom-centered radicals. This will significantly broaden the reaction space of the herein proposed strategy.

亚硝基化合物将被用作各种可见光介导的级联反应中的多功能自由基前体。一个主要的焦点将在于从烷基亚硝基化合物的C-自由基的光化学生成及其在氧化分子间加成反应中的应用。这些级联反应是由持久自由基效应和持久NO自由基介导的转化。亲核性，两亲性和亲电C-自由基将采用这种新的策略进行研究。这些光介导的反应显示出高的原子经济性。沿着光介导的自由基生成，还将研究热变体并解决动力学问题。亚硝基衍生物中的光化学σ键均裂也将应用于杂原子中心自由基的产生。这将显著拓宽本文提出的策略的反应空间。