Novel Transformations Mediated by the Persistent NO Radical

亚硝基化合物在各种可见光介导的级联反应中将被用作多种自由基的前体。重点将集中在烷基亚硝基化合物光化学生成C-自由基及其在氧化分子间加成反应中的应用。这些级联是由持续的自由基效应控制的，而持续的NO自由基介导了这些转变。应用这一新策略将研究亲核、两亲性和亲电性C-自由基。这些光中介反应显示出很高的原子经济性。除了光介导的自由基产生，还将研究热变异体并解决动力学问题。亚硝基衍生物中的光化学Sigma键均解也将被应用于生成以杂原子为中心的自由基。这将大大拓宽本文提出的策略的反应空间。

Nitroso compounds will be used as versatile radical precursors in various visible light mediated cascade reactions. A major focus will lie on the photochemical generation of C-radicals from alkyl nitroso compounds and their application in oxidative intermolecular addition reactions. These cascades are steered by the Persistent Radical Effect and the persistent NO radical mediates the transformations. Nucleophilic, amphiphilic as well as electrophilic C-radicals will be investigated applying this novel strategy. These photo-mediated reactions show high atom economy. Along with the photo-mediated radical generation, thermal variants will also be investigated and kinetics addressed. Photochemical Sigma-bond homolysis in nitroso derivatives will also be applied to the generation of heteroatom-centered radicals. This will significantly broaden the reaction space of the herein proposed strategy.