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Controlled release of volatile mosquito repellents from nanostructured polymers to reduce infectious tropical diseases: Part II: Bicomponent fibers as drug-release device

纳米结构聚合物控制释放挥发性驱蚊剂以减少传染性热带疾病：第二部分：双组分纤维作为药物释放装置

基本信息

批准号：
270456781
负责人：
Professor Dr.-Ing. René Androsch
金额：
--
依托单位：
Department of Chemistry
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2015
资助国家：
德国
起止时间：
2014-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/270456781?language=en
关键词：
Controlled release volatile mosquito repellents

项目摘要

In the first part of the project polymer scaffolds holding different mosquito repellents including DEET, icaridin, or citronellal were developed. Extruded strands were re-designed to footlets and tested with respect to their mosquito-repellence efficacy. The concerted research performed by the individual project partners was targeted to the development of research capacity in Maputo (Mozambique) serving as headquarter for both in-field footlet-acceptance studies and in-field prototype testing. The results obtained prove that the general concept of long-lasting outdoor protection of humans for mosquito attacks, based on polymer-scaffold/drug devices is highly promising, however, with potential for further improvements. As a main result of foot-in-cage tests, it was found that drug-containing strands provide long-lasting local protection but that larger skin coverage is needed for increasing the efficacy of the device. Such larger coverage is suggested being obtained by employing knitted fabrics made from bicomponent fibers hosting large fraction of repellents to be released over long time. Preliminary fiber preparation tests were successfully performed. Based on the new knowledge about the thermodynamics and phase behavior of the biopolymer/drug system PLLA/DEET gained in the first part of project, it is now intended to further develop the idea/approach of preparation of repellent-containing fibers to obtain fabrics able to protect larger skin area for mosquito bites. Research efforts, all remain directed to Mozambique, to build at this location further research and educational capacities and develop people awareness for their own protection.

在该项目的第一部分，开发了容纳不同驱蚊剂的聚合物支架，包括DEET，Escheridin或香茅醛。将挤出的股线重新设计成足，并测试其驱蚊功效。由各个项目合作伙伴开展的协调研究旨在发展马普托（莫桑比克）的研究能力，马普托是现场脚爪验收研究和现场原型测试的总部。所获得的结果证明，基于聚合物支架/药物装置的长期户外保护人类免受蚊子攻击的一般概念是非常有前途的，然而，具有进一步改进的潜力。作为笼中脚测试的主要结果，发现含药物的线股提供持久的局部保护，但需要更大的皮肤覆盖来增加装置的功效。建议通过采用由双组分纤维制成的针织物来获得这种较大的覆盖率，所述双组分纤维承载大部分的待长时间释放的驱避剂。初步的纤维制备试验成功地进行。基于在项目的第一部分中获得的关于生物聚合物/药物系统PLLA/DEET的热力学和相行为的新知识，现在打算进一步开发制备含驱虫剂纤维的想法/方法，以获得能够保护更大皮肤区域免受蚊子叮咬的织物。所有研究工作仍以莫桑比克为对象，以便在这个地方进一步建立研究和教育能力，并提高人们的自我保护意识。