A novel role for the proteins Scribble & Dlg in the formation of cell protrusions and their effects on cell function

蛋白质 Scribble 的新作用

• 批准号: DP0770031
• 负责人: Prof Sarah Russell
• 金额: $ 18.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0770031
• 关键词: novel; role; proteins; Scribble; Dlg

Dlg and Scribble are recently discovered proteins that are required during development, immune regulation, neural signalling and tumour suppression. Understanding how they work will enable the development of diagnostic and therapeutic tools that have the potential to influence an enormous range of diseases, from cancer to immunodeficiencies and autoimmune diseases. Researchers at the PeterMac perform world-leading research into the biology of Scribble and Dlg, and their role in cancer biology and immune function. The mechanistic insight provided by this project will continue that tradition, and facilitate translation of our basic research into clinical applications in important disease areas.

Dlg和Scribble是最近发现的蛋白质，它们在发育、免疫调节、神经信号传导和肿瘤抑制过程中都是必需的。了解它们的工作原理将有助于开发诊断和治疗工具，这些工具有可能影响从癌症到免疫缺陷和自身免疫性疾病等一系列疾病。PeterMac的研究人员对Scribble和Dlg的生物学以及它们在癌症生物学和免疫功能中的作用进行了世界领先的研究。该项目提供的机制见解将延续这一传统，并促进将我们的基础研究转化为重要疾病领域的临床应用。