Elucidating the mechanisms by which Scribble, Discs Large and Lethal Giant Larvae regulate epithelial polarity

阐明 Scribble、Discs Large 和致命巨型幼虫调节上皮极性的机制

• 批准号: DP0451224
• 负责人: Prof Sarah Russell
• 金额: $ 20.17万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-15 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0451224
• 关键词: Elucidating; mechanisms; Scribble; Discs; Large

Discs Large (Dlg) and Scribble are proteins that regulate cell shape by concentrating at particular regions within the cell and recruiting other proteins to that region. It is thought that the two proteins interact with each other, and with other proteins involved in protein trafficking and cell architecture, but it is not known how these events coordinate to produce a net outcome on cell shape. To answer these questions, the dynamic events involved in localization of Dlg, Scribble, and associated proteins will be determined, in mammalian cells and in whole organs of the vinegar fly.

Dlg和Scribble是通过集中在细胞内的特定区域并将其他蛋白质募集到该区域来调节细胞形状的蛋白质。 据认为，这两种蛋白质相互作用，并与其他蛋白质参与蛋白质运输和细胞结构，但目前还不知道这些事件如何协调，以产生对细胞形状的净结果。为了回答这些问题，动态事件参与本地化的Dlg，涂鸦，和相关的蛋白质将被确定，在哺乳动物细胞和整个器官的醋蝇。