Elucidating immune responses by single cell pedigree and tracing analysis

通过单细胞谱系和追踪分析阐明免疫反应

• 批准号: nhmrc : 1099140
• 负责人: Prof Sarah Russell
• 金额: $ 45.71万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-immune-responses-tracing-analysis/662423
• 关键词: Elucidating; immune; responses; single; cell

To develop vaccines and to combat autoimmunity, we need to understand how initial immune activation influences the fate of immune cells and their progeny. To achieve this, we have developed microscopic techniques and analytical software with which to observe how initial signalling processes in the parent immune cell influence the death, proliferation and differentiation of its daughters, granddaughters and further progeny. We will use these approaches to determine how immune cell fate is control

为了开发疫苗和对抗自身免疫，我们需要了解初始免疫激活如何影响免疫细胞及其后代的命运。为了实现这一目标，我们开发了显微镜技术和分析软件，以观察亲本免疫细胞中的初始信号传导过程如何影响其子代、孙女和进一步子代的死亡、增殖和分化。我们将使用这些方法来确定免疫细胞的命运是如何控制的