Elucidating mechanisms for the biological activities of CD46.

阐明 CD46 的生物活性机制。

• 批准号: nhmrc : 350461
• 负责人: Prof Sarah Russell
• 金额: $ 15.2万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-mechanisms-biological-activities-cd46/82515
• 关键词: Elucidating; mechanisms; biological; activities; CD46.

The CD46 protein enables entry into cells of a number of different pathogens, including the measles virus, Neisseria meningitidis (the major cause of meningococcal disease), Neisseria gonorrhoea, Human Herpes Virus 6, and group A streptococcus. In addition, by binding to a key blood component that is often attached to foreign pathogens, CD46 can facilitate binding and entry of other pathogens. As well as facilitating entry of the pathogen, it has recently become apparent that CD46 binding triggers a wide range of responses from the human host. Some of these responses are likely to further facilitate survival and proliferation of the pathogen, but others are more likely to facilitate host defence. For examples, signals triggered by binding to CD46 can both abrogate some aspects of the immune response (and it is though that this immunosuppression contributes to the secondary infections that cause the death of nearly one million children each year) and facilitate other aspects of the immune response. By understanding the mechanisms by which CD46 triggers these complex responses, we firstly be able to dissect how important each of these processes are to the overall pathogenecity of the virus or bacteria. Furthmore, this understanding will allow us to design better vaccines and drugs to combat these diseases.

CD46蛋白能够使许多不同病原体进入细胞，包括麻疹病毒、脑膜炎奈瑟菌（脑膜炎球菌病的主要原因）、淋病奈瑟菌、人类疱疹病毒6和A组链球菌。此外，通过与通常附着于外来病原体的关键血液成分结合，CD46可以促进其他病原体的结合和进入。除了促进病原体的进入，最近已经变得明显的是，CD46结合触发了人类宿主的广泛反应。其中一些反应可能进一步促进病原体的存活和增殖，但其他反应更可能促进宿主防御。例如，通过与CD46结合而触发的信号既可以消除免疫应答的某些方面（并且这种免疫抑制有助于导致每年近一百万儿童死亡的继发感染），又可以促进免疫应答的其他方面。通过了解CD46触发这些复杂反应的机制，我们首先能够剖析这些过程中的每一个对病毒或细菌的整体致病性有多重要。此外，这种理解将使我们能够设计更好的疫苗和药物来对抗这些疾病。