Multifunctional dressing for treatment of diabetic wounds

治疗糖尿病伤口的多功能敷料

• 批准号: 10207665
• 负责人: Mehmet Remzi Dokmeci
• 金额: $ 31.56万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207665
• 关键词: Amputation; Angiogenic Factor; Antibiotics; Bacteria; Bacterial Infections; Bandage; Burn injury; Bypass; Calcium; Cathepsin G; Cell Proliferation; Cell physiology; Cells; Cessation of life; Chronic; Cleaved cell; Collagen; Debridement; Dermal; Devices; Diabetes Mellitus; Diabetic mouse; Dimensions; Disease; Early treatment; Endothelial Cells; Engineering; Environment; Enzymes; Fibroblasts; Financial Hardship; Future; Goals; Growth; Health Care Costs; Healthcare Systems; Hydrogels; Hypertrophic Cicatrix; Hypoxia; Immune; Immune response; Immune system; Impairment; In Vitro; Infection; Infection prevention; Inflammation; Inflammatory; Injury; Mediating; Medical; Metabolic; Microbial Biofilms; Monitor; Morbidity - disease rate; Natural regeneration; Needles; Non-Insulin-Dependent Diabetes Mellitus; Operative Surgical Procedures; Oxygen; Patients; Penetration; Peptides; Peroxides; Physiological; Polymers; Prevalence; Process; Quality of life; Research; Risk; Savings; Scientist; Sepsis; Side; Skin; Societies; Sterile coverings; Stromal Cells; Therapeutic; Tissues; Treatment Effectiveness; Up-Regulation; Vascular Endothelial Growth Factors; Vascularization; Vertebral column; Visit; Water; acute wound; angiogenesis; aqueous; base; chronic wound; clinical practice; comorbidity; controlled release; diabetic patient; diabetic ulcer; diabetic wound healing; effective therapy; enhancing factor; experience; fighting; flexibility; healing; improved; in vivo; individualized medicine; interdisciplinary approach; limb amputation; medical complication; migration; mortality; mouse model; neutrophil; non-diabetic; non-healing wounds; pathogen; prevent; recurrent infection; release factor; reparative process; response; tissue oxygenation; tissue repair; wound; wound bed; wound dressing; wound healing

PROJECT SUMMARY Chronic diabetic wounds (CDW) are one of the most challenging and common medical complications of type-2 diabetes. CDWs are associated with significantly increased costs for healthcare systems and society, decreased quality of life for patients, higher rates of co-morbidities such as recurrent infections and amputations, and an overall dramatically higher mortality rate. The wide prevalence of type-2 diabetes and its constantly increasing impact urgently demand the need for effective treatments aimed at restoring physiological healing of CDWs and preventing associated co-morbidities and mortality. Insufficient skin vascularization and infection inhibit effective healing of CDWs. In non-diabetic injuries, physiologic healing relies on neoangiogenesis and vascularization to restore tissue oxygenation, provide metabolic support to regenerating cells/tissues, and to allow migration of immune cells to counteract pathogens. Instead, in CDWs angiogenesis is impaired resulting in tissue hypoxia, lack of the metabolic support required for tissue repair, and an insufficient immune-response to bacterial infections. These conditions first “lock” CDWs in a chronic inflammatory state unable to progress to tissue repair and second place the patients at risk of sepsis. In severe cases, surgical debridement or limb amputation is the only option for saving patients’ lives. Our hypothesis is that the delivery of VEGF (an angiogenic factor), oxygen combined with on demand release of antibiotics in response to upregulation of neutrophil secretomes can prevent biofilm formation and in turn can reduce the CDW morbidity rate. The goal of this proposal is to engineer bandages containing microneedle arrays that can control release VEGF, oxygen, and can self respond to upregulation of bacteria mediated neutrophil secretomes for inducing healing and avoiding infection.

项目总结 慢性糖尿病创面是2型糖尿病最具挑战性和最常见的内科并发症之一。 糖尿病。CDW与显著增加的医疗系统和社会成本相关， 患者生活质量下降，反复感染等共病发生率上升， 截肢，以及总体上极高的死亡率。2型糖尿病的广泛流行及其原因 不断增加的影响迫切需要旨在恢复 CDW的生理愈合和预防相关的合并症和死亡率。皮肤不足 血管化和感染抑制了CDW的有效愈合。在非糖尿病损伤中，生理性愈合 依靠新生血管生成和血管形成来恢复组织氧合，为 再生细胞/组织，并允许免疫细胞迁移以对抗病原体。相反，在CDW中 血管生成受损，导致组织缺氧，缺乏组织修复所需的代谢支持， 对细菌感染的免疫反应不足。这些情况首先将CDW锁定在慢性疾病中 炎症状态不能进展到组织修复，其次是有脓毒症风险的患者。严重者 在某些情况下，外科清创或截肢是挽救病人生命的唯一选择。我们的假设是 血管内皮生长因子(一种血管生成因子)的输送，氧气和抗生素的按需释放在 对中性粒细胞分泌体上调的反应可以防止生物被膜的形成，进而可以减少 CDW患病率。该方案的目标是设计包含微针阵列的绷带 可以控制血管内皮生长因子、氧气的释放，并能对细菌介导的上调做出自我反应 促进愈合和避免感染的中性粒细胞分泌物。

项目成果

Microneedle arrays for the treatment of chronic wounds.

• DOI: 10.1080/17425247.2020.1819787
• 发表时间: 2020-12
• 期刊: Expert opinion on drug delivery
• 影响因子: 6.6
• 作者: Barnum L;Samandari M;Schmidt TA;Tamayol A
• 通讯作者: Tamayol A

Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.

• DOI: 10.1002/adhm.202001305
• 发表时间: 2021-04
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Rinoldi C;Kijeńska-Gawrońska E;Khademhosseini A;Tamayol A;Swieszkowski W
• 通讯作者: Swieszkowski W

In situ forming microporous gelatin methacryloyl hydrogel scaffolds from thermostable microgels for tissue engineering.

• DOI: 10.1002/btm2.10180
• 发表时间: 2020-09
• 期刊: Bioengineering & translational medicine
• 影响因子: 7.4
• 作者: Zoratto N;Di Lisa D;de Rutte J;Sakib MN;Alves E Silva AR;Tamayol A;Di Carlo D;Khademhosseini A;Sheikhi A
• 通讯作者: Sheikhi A

A Breathable, Passive-Cooling, Non-Inflammatory, and Biodegradable Aerogel Electronic Skin for Wearable Physical-Electrophysiological-Chemical Analysis.

一种透气、被动冷却、非炎症且可生物降解的气凝胶电子皮肤，用于可穿戴物理电生理化学分析。

• DOI: 10.1002/adma.202209300
• 发表时间: 2023
• 期刊: Advanced materials (Deerfield Beach, Fla.)
• 作者: Zhu,Yangzhi;Haghniaz,Reihaneh;Hartel,MartinC;Guan,Shenghan;Bahari,Jamal;Li,Zijie;Baidya,Avijit;Cao,Ke;Gao,Xiaoxiang;Li,Jinghang;Wu,Zhuohong;Cheng,Xuanbing;Li,Bingbing;Emaminejad,Sam;Weiss,PaulS;Khademhosseini,Ali
• 通讯作者: Khademhosseini,Ali

Smart Bandages: The Future of Wound Care.

聪明的绷带：伤口护理的未来。

• DOI: 10.1016/j.tibtech.2018.07.007
• 发表时间: 2018-12
• 期刊: Trends in biotechnology
• 影响因子: 17.3
• 作者: Derakhshandeh H;Kashaf SS;Aghabaglou F;Ghanavati IO;Tamayol A
• 通讯作者: Tamayol A