Dispersion-Directed Lewis Base Catalysis

分散导向路易斯碱催化

• 批准号: 271386062
• 负责人: Professor Dr. Hendrik Zipse
• 金额: --
• 依托单位: Department Chemie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/271386062?language=en
• 关键词: Dispersion; Directed; Lewis; Base; Catalysis

Catalyst systems combining the effects of new Lewis base catalysts and appropriately structured reagents will be developed that allow the form- and size-selective acylation and silylation of substrate alcohols. Catalyst performance will be quantified in reactions with mixtures of substrate alcohols and through kinetic studies on single substrates. Spectroscopic measurements and quantum chemical studies on key intermediates of the catalytic cycle will be performed in order to identify the most relevant factors affecting catalytic performance.

将开发结合新的刘易斯碱催化剂和适当结构化试剂的作用的催化剂系统，其允许底物醇的形式和尺寸选择性酰化和甲硅烷基化。催化剂性能将在与底物醇的混合物的反应中以及通过对单一底物的动力学研究来量化。将对催化循环的关键中间体进行光谱测量和量子化学研究，以确定影响催化性能的最相关因素。

项目成果

Substituent Effects in the Silylation of Secondary Alcohols: A Mechanistic Study.

仲醇硅烷化中的取代效应：机理研究

• DOI: 10.1002/chem.201803014
• 发表时间: 2018
• 期刊: Chemistry
• 作者: M. Marin-Luna;P. Patschinski;H. Zipse
• 通讯作者: H. Zipse