A silicon-based terahertz near-field imaging array for ex vivo life-science applications - Phase 2

用于离体生命科学应用的硅基太赫兹近场成像阵列 - 第 2 阶段

• 批准号: 272340201
• 负责人: Dr. Gaetan MacGrogan
• 金额: --
• 依托单位: Institut Bergonié
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/272340201?language=en
• 关键词: silicon; based; terahertz; near; field

The project's main objective is to leverage silicon-based economies-of-scale for a technology breakthrough in life-science. The aim is to develop a silicon-based THz sub-wavelength imager for tumor margin identification and the results of this interdisciplinary research proposal will help a surgeon to make an instantaneous (intraoperative) decision during an oncological surgery - substantially improving the quality-of-life of a patient. The challenging objective of NearSense requires major innovations in an inter-disciplinary research field. The NearSense research is, therefore, conducted by an interdisciplinary team of physicists, oncologic surgeons, histopathologists and engineers. The scientific breakthrough in the first phase was achieved by a fully-integrated THz near-field sensor pixel comprising of a THz source (transmitter), an electromagnetic near-field sensor element (transducer), a THz detector (receiver) including the readout thereof. The THz near-field sensor pixel provided the dielectric properties (complex permittivity) of bio cells on the micrometer scale. The projects second phase leverages silicon-technologies to integrate large 2-D arrays with real-time acquisition capability to provide a surgeon with high resolution THz video analysis during an oncological surgery. NearSense exploits the benefits of the terahertz radiation with the required sub-wavelength optical resolution for intraoperative bio imaging without the need for scanning.

该项目的主要目标是利用硅基规模经济实现生命科学的技术突破。其目的是开发一种用于肿瘤边缘识别的硅基THz亚波长成像仪，这项跨学科研究提案的结果将帮助外科医生在肿瘤手术期间做出即时（术中）决定-大大提高患者的生活质量。NearSense具有挑战性的目标需要在跨学科研究领域进行重大创新。因此，NearSense研究是由物理学家，肿瘤外科医生，组织病理学家和工程师组成的跨学科团队进行的。第一阶段的科学突破是通过完全集成的THz近场传感器像素实现的，该传感器像素包括THz源（发射器）、电磁近场传感器元件（换能器）、包括其读出的THz检测器（接收器）。太赫兹近场传感器像素提供了微米尺度上的生物细胞的介电特性（复介电常数）。该项目的第二阶段利用硅技术将大型2-D阵列与实时采集功能集成，为外科医生在肿瘤手术期间提供高分辨率THz视频分析。NearSense利用太赫兹辐射的优势，具有术中生物成像所需的亚波长光学分辨率，而无需扫描。