Prospectiv controlled study of singeltons (and multiples) born after intracytoplasmic sperm injection aged 14 to 16 years and their mothers

对 14 至 16 岁胞浆内单精子注射后出生的单胎（和多胎）及其母亲的前瞻性对照研究

• 批准号: 273685972
• 负责人: Professor Dr. Alexander Katalinic
• 金额: --
• 依托单位: Institut für Sozialmedizin und Epidemiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/273685972?language=en
• 关键词: Prospectiv; controlled; study; singeltons; multiples

The German ICSI follow-up I study showed an increased risk of malformation in children after intracytoplasmic sperm injection (ICSI) compared with cases of spontaneous conception. In the ICSI follow-up study II which examined term-born singletons after ICSI at the age of 4-6 years regarding their intellectual and physical development no differences could be found in comparison with cases of spontaneous conception at the same age. However the question is discussed, whether with increasing age, metabolic and hormonal aspects could be of importance. Therefore, in the ICSI follow-up III study we will examine the cohort of children conceived by ICSI who are now at the age of 14-16 years regarding their metabolic and endocrinological health as well as their growth and puberty development in comparison to age and sex-matched cases with spontaneous conception. Furthermore, the metabolic health of the mother will be examined.Additional questions affect the current health status, acute or chronic diseases, hospitalizations and surgeries of the children as well as the psycho-emotional situation in the family, the clarification of the conception and academic development. For the latter questions we will not only compare the singletons born after ICSI with cases of spontaneous conception but also with multiples born after ICSI.In our prospective controlled study mothers and their term-born singletons of the ICSI group, of the control group, and mothers and their multiples born after ICSI should complete a questionnaire (online or paper and pencil). A sub cohort of mothers and their term-born singletons of the ICSI group and of the control group should be examined by their related pediatric physician concerning physical health and metabolic and endocrinological status. For analyses the children will be matched by age, position in the rank of siblings, age of the mother and social status. Due to the fact that the number of families with multiples is low, we will not match them with cases of spontaneous conception. Therefore we constrain the physical and metabolic examination to singletons.The results of the study will contribute to improve the knowledge of long term effects of assisted reproductive technologies especially of ICSI. This knowledge may substantially influence the counseling of parents planning to undergo ICSI and also be important for ICSI children for their own health and reproductive future.

德国ICSI随访I研究显示，与自然受孕病例相比，胞浆内单精子注射（ICSI）后的儿童畸形风险增加。在 ICSI 后续研究 II 中，检查了 4-6 岁时 ICSI 后足月出生的单胎的智力和身体发育情况，与同龄自然受孕的病例相比，没有发现差异。然而，人们讨论的问题是，随着年龄的增长，代谢和荷尔蒙方面是否会变得重要。因此，在 ICSI 后续 III 研究中，我们将检查目前 14-16 岁的 ICSI 受孕儿童队列，与年龄和性别匹配的自然受孕病例相比，了解他们的代谢和内分泌健康状况以及生长和青春期发育情况。此外，还将检查母亲的代谢健康状况。其他问题会影响孩子目前的健康状况、急性或慢性疾病、住院和手术以及家庭的心理情绪状况、概念的澄清和学业发展。对于后一个问题，我们不仅将 ICSI 后出生的单胎与自然受孕的病例进行比较，还将与 ICSI 后出生的多胞胎进行比较。在我们的前瞻性对照研究中，ICSI 组、对照组的母亲及其足月出生的单胎，以及 ICSI 后出生的母亲及其多胞胎应填写一份调查问卷（在线或纸笔）。 ICSI 组和对照组的一组母亲及其足月出生的单胎应由相关儿科医师检查身体健康、代谢和内分泌状态。为了进行分析，孩子们将根据年龄、兄弟姐妹中的地位、母亲的年龄和社会地位进行匹配。由于多胞胎家庭数量较少，我们不会将其与自然受孕的案例进行匹配。因此，我们将身体和代谢检查限制在单胎中。研究结果将有助于提高对辅助生殖技术特别是 ICSI 的长期影响的认识。这些知识可能会极大地影响计划接受 ICSI 的父母的咨询，并且对于 ICSI 儿童自身的健康和生殖未来也很重要。