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Efficay and mechanisms of change of an emotion-oriented version of Cognitive-behavioral Therapy for Psychosis (CBTd-E) in reducing delusions. A randomized-controlled treatment study.

精神病认知行为疗法（CBTd-E）以情绪为导向的版本在减少妄想方面的功效和改变机制。

基本信息

批准号：
275236147
负责人：
Professorin Dr. Tania Lincoln
金额：
--
依托单位：
Arbeitsbereich Klinische Psychologie und Psychotherapie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2015
资助国家：
德国
起止时间：
2014-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/275236147?language=en
关键词：
Efficay mechanisms change emotion oriented

项目摘要

Numerous meta-analyses have found Cognitive Behaviour Therapy for psychosis (CBTp) to be effective. The effect sizes that are achieved for positive symptoms in addition to antipsychotic treatment vary between small to medium. However, the effect sizes for changes in delusions are somewhat lower. Thus, it could prove beneficial to tailor CBTp interventions more precisely to the processes that are relevant to delusions. Empirically derived models of the formation and maintenance of delusions postulate an important role of cognitive biases, emotional factors and self-esteem. Additional studies have demonstrated the relevance of impaired sleep to delusions. Nevertheless, CBTp interventions that aim to change delusions tend to focus mainly on reasoning bias. The results of several uncontrolled pilot studies that focused primarily at improving emotional factors, quality of sleep and self-esteem in patients with delusions indicate that changes in these factors have the potential to reduce delusions. However, in these studies the singular interventions were short and were not implemented into a broader therapy rational. It can thus be assumed that a combination of CBT-interventions within a broader therapy rational might have an even greater impact on delusions. The aim of the present single-blind randomized-controlled therapy study is to assess the efficacy of a new form of Cognitive Behavioral Therapy for delusions with a focus on emotion regulation, improvement of self-esteem and sleep quality (CBTd-E) that will be applied in 25 individual sessions. Moreover, the study aims to test whether the efficacy of CBTd-E is mediated by the postulated processes. The main hypotheses are: 1. Baseline differences: in comparison to healthy controls, patients with schizophrenia show more pronounced problems in emotion regulation, a reduced sleep quality and a lower and less stable self-esteem. 2. Efficacy of CBTd-E: patients with acute delusions who receive CBTd-E show a more pronounced reduction of delusions (primary outcome), as well as a more pronounced reduction of positive symptoms, depression and general psychopathology, a stronger improvement in general and social functioning and will receive lower doses of antipsychotic medication (secondary outcomes) at post-treatment. 3. Mediation: the effect of CBTd-E on change in delusions is mediated by a) improved emotional stability and emotion regulation ability, b) improved sleep quality, c) improved and more stable self-esteem.In addition to questionnaires and interviews, behavioral paradigms, psychophysiological assessments and electronic diaries will be used to test the hypotheses. If we can demonstrate that CBTd-E reduces delusions, this would provide us with a more acceptable and feasible therapy for treating delusions.

许多荟萃分析发现，精神病认知行为疗法（CBTp）是有效的。除了抗精神病药物治疗外，阳性症状所达到的效应量在小到中等之间变化。然而，错觉变化的效应量略低。因此，它可以被证明是有益的，更精确地定制CBTp干预与妄想相关的过程。妄想形成和维持的经验模型假定认知偏差、情感因素和自尊起着重要作用。更多的研究已经证明了睡眠受损与妄想的相关性。然而，旨在改变妄想的CBTp干预措施往往主要集中在推理偏差上。几项主要关注改善妄想症患者的情绪因素、睡眠质量和自尊的非对照试点研究的结果表明，这些因素的变化有可能减少妄想症。然而，在这些研究中，单一的干预措施都很短，没有实施到更广泛的治疗理性。因此，可以假设，在更广泛的治疗理性中，CBT干预的组合可能对妄想产生更大的影响。本单盲随机对照治疗研究的目的是评估一种新形式的认知行为疗法对妄想症的疗效，重点是情绪调节，自尊和睡眠质量的改善（CBTd-E），将在25个单独的会议中应用。此外，该研究旨在测试CBTd-E的功效是否由假设的过程介导。主要假设是：1.基线差异：结论：1.精神分裂症患者与健康对照组相比，情绪调节问题更明显，睡眠质量更差，自尊心更低且更不稳定。CBTd-E的疗效：接受CBTd-E治疗的急性妄想患者表现出妄想更明显的减少（主要结果），以及阳性症状、抑郁和一般精神病理学更明显的减少，一般和社会功能更强的改善，并且在治疗后将接受更低剂量的抗精神病药物（次要结果）。调解：CBTd-E对妄想改变的影响是通过a）改善情绪稳定性和情绪调节能力，B）改善睡眠质量，c）改善和更稳定的自尊来介导的。如果我们能够证明CBTd-E可以减少妄想，这将为我们提供一种更可接受和可行的治疗妄想的疗法。