Dissociation of a Tetrameric Enzyme with Interface-Targeted Peptides

四聚体酶与界面靶向肽的解离

• 批准号: DP0770888
• 负责人: A/Prof Matthew Perugini
• 金额: $ 18.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0770888
• 关键词: Dissociation; Tetrameric; Enzyme; Interface; Targeted

With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics and an equally urgent need to characterise new antibiotic targets. One such target is dihydrodipicolinate synthase (DHDPS) which catalyses the critical step in lysine and cell wall biosynthesis in bacteria. This proposal aims to generate new drugs targeting DHDPS for effective and rapid treatment of bacterial infections, including gastroenteritis. Recent statistics show that over 5 million Australians suffer from gastroenteritis each year and hospitalisation for this infection is nearly seven times higher for indigenous than non-indigenous children. Accordingly, this research has the potential to assure a healthier future for millions of Australians.

随着抗生素耐药性的增加，迫切需要开发新的抗生素，同样迫切需要寻找新的抗生素靶标。一种这样的靶标是二氢吡啶二羧酸合酶（DHDPS），其催化细菌中赖氨酸和细胞壁生物合成中的关键步骤。该提案旨在产生针对DHDPS的新药，用于有效和快速治疗细菌感染，包括胃肠炎。最近的统计数字表明，每年有500多万澳大利亚人患胃肠炎，土著儿童因这种感染住院的人数几乎是非土著儿童的7倍。因此，这项研究有可能确保数百万澳大利亚人的健康未来。