Molecular evolution of a model oligomeric enzyme from bacterial extremophiles

细菌极端微生物模型寡聚酶的分子进化

• 批准号: FT0991245
• 负责人: A/Prof Matthew Perugini
• 金额: $ 48.96万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT0991245
• 关键词: Molecular; evolution; model; oligomeric; enzyme

The national benefits of this research program include insight into the sustainability of marine microorganisms that play an important role in Australia's diverse ecosystem, the development and applications of frontier technologies including high-performance computing on the world's largest supercomputer facility for life science research, and knowledge impacting on the discovery of novel antibiotics that target pathogenic bacteria, like Golden Staph. This program will also train several young Australians in highly sought after skills, including bacteriology, biophysics, enzymology, molecular biology, molecular modelling, protein chemistry and structural biology.

这项研究计划的国家利益包括深入了解在澳大利亚多样化生态系统中发挥重要作用的海洋微生物的可持续性，前沿技术的开发和应用，包括世界上最大的超级计算机设施上的高性能计算生命科学研究，以及对发现针对病原菌的新型抗生素的知识产生影响，如金色葡萄球菌。该计划还将培养几名澳大利亚年轻人在高度追捧的技能，包括细菌学，生物物理学，酶学，分子生物学，分子建模，蛋白质化学和结构生物学。