The ApoE Interactome in Human Plasma

人血浆中的 ApoE 相互作用组

• 批准号: DP0556836
• 负责人: A/Prof Matthew Perugini
• 金额: $ 24.47万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0556836
• 关键词: ApoE; Interactome; Human; Plasma

In this, the post-genome era, the emphasis has switched from the delineation of genome structure to the tremendous task of characterizing the gene products. One of the important aspects evolving in this new era is the design of strategies that enable identification of global protein-protein interactions, defined by the Human Proteome Organisation as the interactome. This, the apoE interactome in human plasma project, will identify novel interactions between plasma proteins and apoE, which is a lipid-binding protein genetically linked to age-related diseases affecting more than 500,000 Australians. This project will therefore provide scope for novel treatments and early detection of disease, namely cardiovascular and Alzheimer's disease.

在这个后基因组时代，重点已经从基因组结构的描绘转向了表征基因产物的巨大任务。在这个新时代发展的重要方面之一是设计策略，使全球蛋白质相互作用的识别，由人类蛋白质组组织定义为相互作用组。这项名为apoE人类血浆相互作用组的项目将确定血浆蛋白与apoE之间的新型相互作用，apoE是一种与影响50多万澳大利亚人的年龄相关疾病有遗传联系的脂质结合蛋白。因此，该项目将为新型治疗方法和疾病（即心血管病和阿尔茨海默病）的早期检测提供空间。