The LINK to Regulating Lysine Levels in Wheat

调节小麦赖氨酸水平的链接

• 批准号: DP150103313
• 负责人: A/Prof Matthew Perugini
• 金额: $ 23.8万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150103313
• 关键词: LINK; Regulating; Lysine; Levels; Wheat

This project aims to characterise a recently discovered allosteric mechanism called 'Ligand-Induced association by Lysine (K)' (LINK) model. LINK model regulates the function of a key biosynthetic enzyme in bacteria and plants, including agriculturally-important species such as wheat. Also, it represents a highly significant discovery to the field of biochemistry. The expected outcomes of this project include an in-depth understanding of the molecular basis of a new allosteric mechanism for regulating intracellular lysine levels, which in the longer term offers excellent potential to be manipulated for agricultural benefits.

这个项目旨在描述一个最近发现的变构机制，称为“赖氨酸(K)配体诱导缔合”(LINK)模型。LINK模型调节细菌和植物中的一种关键生物合成酶的功能，包括对农业重要的物种，如小麦。此外，这也是生物化学领域的一项非常重要的发现。该项目的预期成果包括深入了解调节细胞内赖氨酸水平的新变构机制的分子基础，从长远来看，这一机制具有极好的农业效益。