Transduction of neuronal signals by brain macroglial cells: implications for neuronal function

脑大胶质细胞转导神经元信号：对神经元功能的影响

• 批准号: DP0770955
• 负责人: Prof David Williams
• 金额: $ 18.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0770955
• 关键词: Transduction; neuronal; signals; brain; macroglial

Study of mechanisms regulating brain cell (neuron and glial) communication is essential for understanding of normal brain function and transformations that occur in neurodegenerative states and age-related disorders. Mechanisms underlying neuron-glia communication are not well understood. By combining cell physiology, digital imaging technologies, and genetically designed and delivered molecules we will enhance our understanding of this brain cell communication and critical roles played by intracellular calcium. This will enhance international competitiveness of Australian biological research and provide novel insight of glial function in neurodegeneration and potential for specific therapeutic intervention in disease.

研究调节脑细胞（神经元和神经胶质）通信的机制对于理解神经退行性疾病和年龄相关疾病中发生的正常脑功能和转变至关重要。神经元-胶质细胞通讯的机制还不清楚。 通过结合细胞生理学，数字成像技术和遗传设计和传递的分子，我们将提高我们对这种脑细胞通信和细胞内钙所起的关键作用的理解。这将提高澳大利亚生物学研究的国际竞争力，并为神经退行性疾病中的神经胶质功能和特异性治疗干预提供新的见解。