A novel mechanism for intestinal propulsion: transit without neurons or pacemakers

肠道推进的新机制：无需神经元或起搏器的运输

• 批准号: nhmrc : 454351
• 负责人: Prof David Williams
• 金额: $ 17.13万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-mechanism-intestinal-neurons-pacemakers/95515
• 关键词: novel; mechanism; intestinal; propulsion; transit

A significant complication of premature births is that the mechanisms that regulate normal intestinal movements have not yet fully developed. We have recently identified a novel pattern of contraction that is seen predominantly in the colon of mice that have not yet developed either the normal nerve circuits that control gut movement and also lack the pacemaker cells that are intrinsic to the muscle coat. This motor pattern appears to be responsible for the movement of gut content during the development and maturation of the nerve circuits that regulate this process in more adult animals. However, the mechanisms responsible for this process have not been identified. This project is directed at identifying these mechanisms

早产的一个重要并发症是调节正常肠道运动的机制尚未完全发育。我们最近发现了一种新型的收缩模式，这种模式主要出现在小鼠的结肠中，这些小鼠尚未发育出控制肠道运动的正常神经回路，也缺乏肌层固有的起搏细胞。这种运动模式似乎是负责在发育和成熟的神经回路，调节这一过程中，在更多的成年动物的肠道内容物的运动。然而，负责这一进程的机制尚未确定。本项目旨在确定这些机制