Calcium signalling in neurons of the central nervous system

中枢神经系统神经元中的钙信号传导

• 批准号: DP0449696
• 负责人: Prof David Williams
• 金额: $ 19.85万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-13 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0449696
• 关键词: Calcium; signalling; neurons; central; nervous

Understanding of the processes of cell-to-cell communication between neurons that comprise the brain and central nervous system is of primary importance to our understanding of fundamental phenomena such as voluntary and reflex movement, sensory responses and learning and memory. We would like to obtain a better understanding of how calcium controls neuronal and synaptic function. These studies will combine high-speed fluorescence imaging, electrophysiological recording, gene transfer using Adeno- and Sindbis viruses, and genetically designed and targeted biosensors to describe key "descriptors" of the calcium signals generated as neurons of the central nervous system ?talk? to each other.

了解组成大脑和中枢神经系统的神经元之间的细胞间通讯过程对于我们理解基本现象如自主和反射运动、感觉反应以及学习和记忆具有重要意义。我们希望更好地了解钙是如何控制神经元和突触功能的。这些研究将结合高速荧光成像、电生理记录、使用腺病毒和Sindbis病毒的基因转移，以及基因设计和有针对性的生物传感器来描述作为中枢神经系统神经元产生的钙信号的关键“描述符”。为了彼此。