Macromolecular Condensates: From Globules to Toroids and Beyond

高分子凝聚体：从球体到环形及其他

• 批准号: DP0664428
• 负责人: Prof David Williams
• 金额: $ 18.72万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664428
• 关键词: Macromolecular; Condensates; Globules; Toroids; Beyond

Polymers are long-chain molecules which are vital for all living things. Examples include proteins and DNA which carries all of the information needed for life. In the cell and in the laboratory these polymers are often found in a compact folded state. Current polymer science is good at describing very flexible polymers, but fails to describe most biological polymers which have backbones that are difficult to bend. Our aim is to describe the folded or globular state for many kinds of biological polymers and thus improve our understanding of the role of polymers in living things.

聚合物是对所有生物都至关重要的长链分子。例如蛋白质和DNA，它们携带着生命所需的所有信息。在细胞中和实验室中，这些聚合物经常以紧密折叠的状态被发现。目前的聚合物科学擅长描述非常灵活的聚合物，但不能描述大多数具有难以弯曲的骨架的生物聚合物。我们的目的是描述多种生物聚合物的折叠或球状状态，从而提高我们对聚合物在生物中的作用的理解。