Multistep chip reactors with an integrated continuous separation

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In Project 7 chip-based multistep flow reactors are being developed, which allow a continuous synthesis in two stages with an intermediate micro free flow electrophoresis. The fabrication, adaptation and application of combined microreactor-microFFE platforms for organic synthesis will be pursued. For method development the synthesis of quinoline-substituted cyclopentenes is investigated. The main product of the synthesis is to be separated from a by-product in the microFFE. Subsequently, the integration of a second reactor stage downstream to the preparative separation, which is suitable for increased temperatures and which allows to control and monitor the temperature on the micro scale, will be performed. In this flow reactor stage a Diels-Alder reaction to build up a multicyclic system in the quinoline side chain is to be carried out. Optical fluorescence detection in the UV region for inline monitoring of chemical reactions and separations will be developed and the coupling of multistage reactors to (bio-)impedance spectroscopy will demonstrated to enable an integrated biosensor. Via the integration of these functions, a continuous multistep organic synthesis, which requires a separation step, on a single microfluidic chip and its inline monitoring and biological testing will be enabled for the first time.